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Pharmacology (2014-2018) > Cholinergic receptors and agents > Flashcards

Cholinergic receptors and agents Flashcards

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1
Q

Reserpine

A. Synthesis
B. Storage
C. Release
D. Receptor
E. Degradation
A

B

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2
Q

Pyridostigmine

A. Synthesis
B. Storage
C. Release
D. Receptor
E. Degradation
A

E

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3
Q

Botulinum toxin

A. Synthesis
B. Storage
C. Release
D. Receptor
E. Degradation
A

C

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4
Q

Vesamicol

A. Synthesis
B. Storage
C. Release
D. Receptor
E. Degradation
A

B

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5
Q

Atropine

A. Synthesis
B. Storage
C. Release
D. Receptor
E. Degradation
A

D

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6
Q

Beta-bungarotoxin

A. Synthesis
B. Storage
C. Release
D. Receptor
E. Degradation
A

C

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7
Q

Malathion

A. Synthesis
B. Storage
C. Release
D. Receptor
E. Degradation
A

E

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8
Q

Magnesium

A. Synthesis
B. Storage
C. Release
D. Receptor
E. Degradation
A

C

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9
Q

Edrophonium

A. Synthesis
B. Storage
C. Release
D. Receptor
E. Degradation
A

E

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10
Q

A patient is rushed to the ER after ingesting an unknown substance. On examination, the patient was restless, had miotic pupils, excessive salivation and lacrimation, and wheezes were noted on auscultation of the lungs. Given the following drugs, which of the following would most
likely be the drug ingested?

A. Trimetaphan
B. Vesamicol
C. Scopolamine
D. Parathion

A

D

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11
Q

Which of the following has the greatest susceptibility to cholinesterase?

A. Methacholine
B. Acetylcholine
C. Carbachol
D. Bethanecol

A

B

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12
Q

Pyridostigmine may cause all of the following EXCEPT

A. Bronchoconstriction
B. Constipation
C. Reversible inhibition of acetylcholinesterase
D. Nicotine effects at the neuromuscular end plate
E. Spasm of accommodation

A

B

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13
Q

Which of the following is used mainly in the diagnosis of myasthenia gravis?

A. Physostigmine
B. Ecothiopate
C. Edrophonium
D. Parathion

A

C

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14
Q

Which of the following is used in the treatment of glaucoma?

A. Pyridostigmine
B. Pilocarpine
C. Parathion
D. Neostigmine

A

B

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15
Q

Which of the following is the rate-limiting step in the synthesis of acetylcholine?

A. Active transport of choline into the cell
B. Entry of neurotransmitter
C. Acetylation of choline with acetylCoA
D. Hydrolysis of acetylcholine

A

A

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16
Q

Which of the following is a centrally acting cholinesterase inhibitor used in the treatment of Alzheimer’s type of dementia?

A. Pyridostigmine
B. Rivastigmine
C. Edrophonium
D. Pilocarpine

A

B

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17
Q

Which neuromuscular blocker has the shortest duration of action?

A. Succinylcholine
B. Pancuronium
C. Tubocurarine
D. Mivacurium

A

B

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18
Q

Which of the following is an effect of an autonomic ganglion stimulant?

A. Postural hypotension
B. Gastrointestinal paralysis
C. Impaired micturition
D. Tachycardia

19
Q

This group of neuromuscular blockers generally has a duration of action of more than 20 minutes

A. Non-depolarizing blocker
B. Depolarizing blocker

20
Q

Malignant hyperthermia is a common complication

A. Non-depolarizing blocker
B. Depolarizing blocker

21
Q

Tetanic stimulation readily reverses the neuromuscular block early in the action of neuromuscular blocker

A. Non-depolarizing blocker
B. Depolarizing blocker

22
Q

True about cholinergic transmission except:

    A. An action terminated by diff. and uptake
    B. Hemicholinum – Entry of choline into nerve terminal
    C. Something – Transport of NT into vesicle
    D. Fusion with PM is Ca2+-dependent
    E. Botox – Fusion of vesicle with PM
23
Q

Which of the following serotonin receptors is ligand-gated?

   A. 5HT 1A
   B. 5HT 2C
   C. 5HT 3
   D. 5HT 4
24
Q

Characteristic of molecule that will cross the blood-brain barrier:

   A. Bound to plasma protein
   B. Large molecule
   C. Lipid soluble
   D. Hydrophilic
25
What is a characteristic of membrane delimited metabotropic receptors? A. G-something directly acts on ion channels B. Activates presynaptic Ca channels C. Inhibits postsynaptic K channels D. Predominates in hierarchial pathways
*
26
Which of the following NT activates only G protein-coupled receptors? A. GABA B. Norepinephrine C. Acetylcholine D. Serotonin
B
27
Atropine effect except: A. Cycloplegia B. Dry mouth C. Hypotension D. Mydriasis
C
28
Which of the following neuromuscular blocker has the shortest duration? A. Pancuronium B. Tubocurarine C. Mivacurium D. Succinylcholine
D
29
Which of the following is an effect of autonomic ganglion blocker? A. Increase in blood pressure B. Increase in bronchial secretions C. Postural hyportension D. Tachycardia
*
30
Non-depolarizing blocking drugs do not produce significant autonomic effects. A. True B. False
B
31
Which of the following agents acting on the autonomic ganglia is used clinically to treat hypertension? A. Trimetaphan B. Hexamethonium C. Epibatidine D. Lobeline
A
32
Which drug is responsible for blocking the transport of Ach and forms false neurotransmitter? A. Vesamicol B. Triethylcholine C. Botulinum toxin D. Hexamithonium
B
33
Which drug is responsible for blocking the transport of Ach and forms false neurotransmitter? A. Vesamicol B. Triethylcholine C. Botulinum toxin D. Hexamithonium
B
34
A patient who has renal insufficiency is to undergo surgery for removal of a renal cyst. If use of a neurotransmitter blocker is warranted, which of the following would probably be the safest to use? A. Tubocurarine B. Atracurium C. Pancuronium D. Doxacurium
B
35
Pralidoxime splits the phosphorylated convalent bonds if given early in organophosphate poisoning. A. True B. False
A
36
Large doses of cholinesterase inhibitors have no effect on autonomous innervation. A. True B. False
B
37
Depolarizing and nondepolarizing neuromuscular blockers bear structural resemblance to acetylcholine. A. True B. False
A
38
Non-depolarizing blocking drugs do not produce significant autonomic effects. A. True B. False
B
39
Tetanic stimulation removes blockade in depolarizing phase 1. A. True B. False
B
40
``` Ecothiopate A. Synthesis B. Storage C. Release D. Receptor E. Degradation ```
E
41
Mg 2+ ``` A. Synthesis B. Storage C. Release D. Receptor E. Degradation ```
C
42
a-bungarotoxin ``` A. Synthesis B. Storage C. Release D. Receptor E. Degradation ```
D
43
A patient is rushed to the emergency room after ingesting an unknown substance. On examination, the patient was restless, had miotic pupils, excessive salivation and lacrimation and wheezes were noted on auscultation of the lungs. Given the following drugs, which of the following would most likely be the drug ingested? A. Neuromuscular blockers B. Botulinum toxin C. Organophosphates D. Datura stramonium
C

Pharmacology (2014-2018) (23 decks)

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