Cholinergics Flashcards Preview

Pharmacology > Cholinergics > Flashcards

Flashcards in Cholinergics Deck (65):
1

M1

Nerves Gq

2

M2

Heart nerves smooth muscle
Gi

3

M3

Glands SM, endothelium
G1

4

M4

CNS Gi

5

M5

CNA Gq

6

Nm

Skeletal muscle
Pentameric a2bdelta game/epsilon
NaK depolarizing channel

7

Non

Postganglionic cells body , dendrites, CNS
A and b only
Na K depolarizing ion channel

8

Entropic

Misalignment of the eyes caused by hypermetropic accommodative error

9

Eye

M2, M3

10

Heart SA/AV

M2

11

Atria

M2

12

Ventricle

M2

13

Endothelium

M3

14

Glands

M2,3

15

Lung

M2,M3

16

Lung

M2,M3

17

GI

M2,M3

18

CNS

M1-M5

19

Most organs

M3 predominant

20

Heart

M2

21

Smooth muscle

M2,3

22

What direct agonists are susceptible to acetylcholinesterase

Methacholine a bit not carb or beth

23

Which direct cholinergic agonist has nicotonic cation

Carabachol

24

Muscadine

Charged but can cross the BBB and is highly toxic (muschrooms)

25

AChe inhibitors

Alcohols (reversible)
Carbamic acid esters-reversible but no longer lasting than alcohols
Organophosphate -irreversible (covalent)

26

Charged AChE inhibitor

Insoluble in lipids
Do not cross BBB, poor PO absorption
Edrophonium, pyridostigmine, neostigmine, echothiophate, ambenonium

27

Neutral AChe inhibitors

Can cross BBB and readily absorbed
Organophosphates
Tertiary agents (physostigmine, donepezil, galantamine, rivastigmine, tacrine)

28

Cevimeline

Direct acting cholinergic Oral tablet used to treat dry mouth in patients with sjorgen

29

Varenicline

Smoking cessation
Partial agonist bindsa4b2 Nn

Stimulation and sustained release of mesolimbic dopamineare thought to reduce craving and withdrawal symptoms

30

Adverse effects varenicline

Nausea, neuropsychiatric (behavior changes, agitation, depressed, suicidal, suicide)

31

Uses for direct acting cholinergic

Post op ileus, congenital megacolon, urinary retention, esophageal reflux, zerosterma, sjorgen

32

Who are muscarinic stimulants contraindicated in

Asthma, hyperthyroidism, coronary insuffiency, acid peptic disease

33

How get nicotine poisoning

Cigarettes and insecticides

34

Symptoms of nicotonic poisoning

CNS stimulation, skeletal muscle and end plat depolarization, respiratoy paralysis, hypertension, cardiac arrhythmia

35

How treat ACH toxicity

Atropine and an anticonvulsant(diazepam a anticonvulsant)

36

Drugs used for ophthalmology

Atropine, cyclopentolate, homatropine, scopolamine, tropicamide

37

Drugs for respirator

Tiotropium

38

Urinary drugs

Darifenacin
Oxybutaynin
Solifenacin
Tolterodine
Trospium

39

Drugs for movement disorders

Benztropine
Biperiden
Orphenadrine
Procylidine
Trihexyphenidyl

40

What are homatropine and atropine used for

Prevent synechia formation in uveitisand iritis -long acting mydriasis and cycloplegia for 14 days

41

Ipratopium and tiotropium

Tiotropium is longer

42

Bladder receptor to prevent urgency for anticholinergic

M3

43

What selective M3 drugs for preventing urinary urgency

Darifenacin, solifenacin, tolterodine
Longer half lives and reduced xerosterma and constipation

44

Contraindications for anticholinergics

Glaucoma
Prostatic hyperplasia
Acid peptic disease

45

Dopamine agonist

Fenoldpam D1 receptor
(Dopamine equal D1=D2)

46

Partial B agonists

Acebutolol
Labetalol
Pindolol
Penbutolol

47

Penbutolol

B1 and B2 non selective blocker

48

Partial b agonist and ISA

Block sympathetic effects but have submaximal effects
Less risk for bradycardia, increases VLDL/HDL and other effects of beta receptor blockade

49

Adverse effects of beta blockers

Sedation, sleep disturbances, depression
Increase VLDL and decrease HDL with chronic use
May exacerbate hypoglycemia in type 1 diabetes patients on insulin

50

Cocaine

Indirect adrenomimetics
Inhibits re uptake of DA and NE

51

Selegiline and phenelzine

Indirect adrenomimetics
Inhibitors of MAO

52

Amphetamines, methylphenidate, tyramine

Indirect adrenomimetics
Reverse NA and DA uptake mechanism and increase their release

53

Silicosis

A1 selective

54

Emphetamine and methamphetamine

Marked stimulant effect on mood and alertness
Decrease appetite
Drug abuse

55

Methylphenidate

Used in children with ADHD similar to amphetamine but has an abuse potential

56

Cocain

Inhibitors transmitter reuptake at adrenergic synapses
Peripheral and intense central action
Local anesthetic properties
Heavily abused

57

Phenelzine and selegiline

Inhibitors of MAO
Increase NE stores in CNA
Antidepressant action

58

Tyramine

Indirect adrenergic agonist
Product of tyrosine metabolism that is found in cheese, meats, smoked and pickled fish

Releases stored NE from presynaptic adrenergic terminals
Metabolized by MAO in liver
May lead to increase in BP in patients taking MOA inhibitors

59

Metytosine

Indirect acting inhibits synthesis of tyrosine hydroxilare at pre synaptic neuron

60

Guanethidine

Indirect acting prevents storage and depletes NE at synapse

61

Direct acting

Right on post synaptic neuron

62

Cocain

Indirect acts at synapse preventing reuptake

63

Phenelzine

MOA inhibitor in presynaptic neuron indirect

64

Amphetamine and ephedrine

Synapse release agent

65

Direct acting

On post synaptic neuron