Cholinomimetic Drugs Flashcards Preview

Autonomic Pharm > Cholinomimetic Drugs > Flashcards

Flashcards in Cholinomimetic Drugs Deck (12):
1

Bethanechol

Direct agonist
Activates bowel and bladder smooth muscle
Resistant to AChE
No nictonic activity

*Used for: post-op ileus, neurogenic ileus, urinary retention

2

Carbachol

Direct agonist
Carbon copy of ACh
Resistant to AChE

*Constricts pupil and relieves intraocular pressure in open-angle glaucoma

3

Methacholine

Direct agonist
Stimulates muscarinic receptors in airway when inhaled

*Challenge test for diagnosis of asthma

4

Pilocarpine

Direct agonist
Contracts ciliary muscle of eye (open-angle glaucoma) and pupillary sphincter (closed-angle glaucoma)
Resistant to AChE
Can cross BBB (tertiary amine)

*Potent stimulator of sweat, tears, and saliva (cry/drool/sweat on pilo)
*Open-angle and closed-angle glaucoma, xerostomia (Sjogren syndrome)

5

Galantamine

Indirect agonist (anticholinesterase)
Increase ACh

*Alzheimer disease

6

Donepezil

Indirect agonist (anticholinesterase)
Increase ACh

*Alzheimer disease

7

Rivastigmine

Indirect agonist (anticholinesterase)
Increase ACh

*Alzheimer disease

8

Edrophonium

Indirect agonist (anticholinesterase)
Increase ACh

*Historically used to diagnose MG-replaced by anti-AChR Ab test

9

Neostigmine

Indirect agonist (anticholinesterase)
Increase ACh
NO CNS penetration (quaternary amine)

*Post-op and neurogenic ileus and urinary retention, MG, reversal of NMJ blockade post-op

10

Physostigmine

Indirect agonist (anticholinesterase)
Increase ACh
Physostigmine "phyxes" atropine overdose
Freely cross BBB (tertiary amine)

*Antidote for anticholinergic toxicity

11

Pyridostigmine

Indirect agonist (anticholinesterase)
Increase ACh
Increase muscle strength
Does NOT penetrate CNS (quaternary amine)

*Long-acting MG treatment

12

Cholinesterase inhibitor poisoning

Irreversible inhibition of AChE = TOO much ACh

*Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle and CNS, Lacrimation, Sweating, Salivation

May lead to respiratory failure if untreated

*Antidote = atropine (competitive inhibitor) + pralidoxime (regenerates AChE if given early)