Muscarinic Antagonists Flashcards Preview

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Flashcards in Muscarinic Antagonists Deck (16):
1

Atropine

Eye: produce mydriasis and cycloplegia (block M3)
Airway: decrease secretions
Stomach: decrease acid secretion
Gut: decrease motility
Bladder: decreased urgency in cystitis
*Blocks DUMBBeLSS in cholinesterase inhibitor poisoning

2

Homatropine

Works in eye
Produce mydriasis and cycloplegia (M3)

3

Tropicamide

Works in eye
Produce mydriasis and cycloplegia (M3)

4

Benztropine

Works in CNS
Used in Parkinson disease and acute dystonia

5

Trihexyphenidyl

Works in CNS
Used in Parkinson disease and acute dystonia

6

Glycopyrrolate

Works in GI, respiratory
Parenteral: preoperative use to reduce airway secretions
Oral uses: drooling, peptic ulcer

7

Hyoscyamine

Works in GI
Use: antispasmodic for IBS

8

Dicyclomine

Works in GI
Use: antispasmodic for IBS

9

Ipratropium

Works in respiratory
Use: COPD, asthma (M3)

10

Tiotropium

Works in respiratory
Use: COPD, asthma (M3)

11

Oxybutynin

Works in GU
Use: reduce bladder spasms and urge urinary incontinence (overactive bladder)

12

Solifenacin

Works in GU
Use: reduce bladder spasms and urge urinary incontinence (overactive bladder)

13

Tolterodine

Works in GU
Use: reduce bladder spasms and urge urinary incontinence (overactive bladder)

14

Scopolamine

Works in CNS
Use: motion sickness (M1)

15

Atropine adverse effects

Hot as a hare--increased body temperature (decreased sweating)
Dry as a bone--dry mouth, dry skin
Red as a beet--flushed skin
Blind as a bat--cycloplegia
Mad as a hatter--disorientation
*Also causes constipation
*Can = acute angle-closure glaucoma in elderly (mydriasis), urinary retention in men with BPH, and hyperthermia in infants

16

Jimson weed (Datura)

Gardener's pupil (mydriasis due to plant alkaloids)
-Muscarinic antagonist