Chp 5—T-cells

Question 1

chain type in T cell receptor

Answer 1

2 light chains, alpha and beta

Question 2

___ always present on T cell receptor

Answer 2

MC

Question 3

____ complexes are associated with T cell receptor on either side:

Answer 3

CD3

𝜺δ dimer
𝛄𝜺 dimer

Question 4

T cell receptor signal transduction conducted by…

where?

Answer 4

𝜁-dimer

sits beneath receptor in cell

Question 5

2 t cell receptor isotypes and prevalence

Answer 5

𝛼:β receptor - most common

𝛄:δ receptor - occurs more in tissues, function varies by animal

Question 6

binding regions of T cell receptor

Answer 6

CDR1
CDR2
CDR3

Question 7

T cells only bind antigen when…

Answer 7

it’s presented on an MHC

Question 8

produces majority of diversity in T cell receptor

Answer 8

junctional diversity - 1000x more than in B cells

Question 9

more diversity in T cell or B cell receptors?

Answer 9

T cell

Question 10

2 cellular immune systems & what they do (briefly)

Answer 10

vesicular system —extracellular pathogens —MHCII —CD4 T cell activation

cytosolic system —intracellular pathogens —MHCI —CD8 T cell activation

Question 11

cells that vesicular system occurs in

Answer 11

B cells & phagocytes

Question 12

_____ T cells bind with MHCII

Answer 12

CD4

Question 13

type 1 vs type 2 CD4 cells

Answer 13

type 1: binds macrophages, triggering cellular immune response

type 2: bind B cells, triggering humoral immune response

Question 14

licensed cells

Answer 14

MHCI is present with self-peptides

NK passes it by

Question 15

____ T cells bind with MHCI

Answer 15

CD8

Question 16

CD8 triggers…

Answer 16

apoptosis

Question 17

polypeptides composing MHCI

Answer 17

β2-microglobulin
𝛼1, 𝛼2, 𝛼3

Question 18

antigen bound between ___ and ___ on MHCI

Answer 18

𝛼1 and 𝛼2

Question 19

MHCI peptide length

Answer 19

8 AA

Question 20

CD8 protein contacts ____ to stabilize bond

Answer 20

𝛼3

Question 21

polypeptides composing MHCII

Answer 21

β1, β2, 𝛼1, 𝛼2

Question 22

antigen bound between ___ and ___ on MHCII

Answer 22

𝛼1 and β1

Question 23

MHCII peptide length

Answer 23

25 AA

Question 24

CD4 proteins contact ___ & stabilize bond

Answer 24

β2

Question 25

function of proteasome/immunoproteasome

Answer 25

barrel-shaped protein that degrades cytosolic proteins

Question 26

function of constitutive proteasome

Answer 26

cleans up damaged, misfolded, or unneeded normal cellular proteins, providing self-peptides for presentation

Question 27

triggers modification into immunoproteasome

Answer 27

IFN-𝛄

Question 28

fragments from proteasome enter ER through

Answer 28

TAP

Question 29

forms around its antigen

Answer 29

MHCI

Question 30

proteasome and TAP involved in MHC__ presentation

Answer 30

I

Question 31

MHCII antigens originally come from...

Answer 31

endosome/pinocytosis

Question 32

hide in phagosome, preventing presentation

Answer 32

Mycobacterium leprae and tuberculosis

Question 33

MHCI monomorphic aspect

Answer 33

B2-microglobulin

Question 34

6 genes for MHCI alpha subunits

Answer 34

A, B, C, E, F, G

Question 35

_____ are highly polymorphic - they present antigen to CD8 T-cells

Answer 35

A, B, C

Question 36

_____ present antigen to NK cells

Answer 36

E, G

Question 37

acts as chaperone to assemble other MHCI complexes

Answer 37

F

Question 38

5 gene pairs for alpha and beta subunits on MHCII

Answer 38

DP, DO, DM, DQ, DR

Question 39

_____ present antigen to CD4 cells

Answer 39

DP, DQ, DR

Question 40

________ are involved in assembling MHCII complexes

Answer 40

DM & DO

Question 41

transcriptional activator - turns on MHCII genes as well as TAP and immunoproteasome genes

Answer 41

MHC class II transactivator (CIITA)

Question 42

specific amino acids which must be present

Answer 42

anchor residues/peptide-binding motifs

Question 43

MCH restriction

Answer 43

the T-cell receptor must be specific to both the antigen and the HLA isoform