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Flashcards in Chronic Inflammation Deck (22):
1

What is another term for Chronic inflammation and what cell type is mostly present?

Modulated
Macrophage

2

Name 2 mononuclear cells

Lymphocytes and macrophages

3

When does it develop?

1. without acute - TB
2. Alongside Acute-Bacterial Infection
3. After Acute

4

What are Macrophages in the blood and when are they called that?

Monocytes in blood
Macrophages in the tissue

5

What new tissue forms?

Granulation tissue

6

Difference between Macrophages and neutrophils?

Macrophages circulate in blood for 6 days and can replicate whilst neutrophils die after a few days and are end cells

7

Neutrophil functions:

Phagocytosis
Anti presentation
Activate other cells by cytokines
Inducing fibrous
Inducing Fever- Acute Phase Reaction - Cachexia

8

T and B Lymphocytes function

Process Antigens
Secreting Antibodies - B
Secreting Cytokines
Killer cells by Natural killer cells

9

Eosinophils

Attack parasites and allergic reactions

10

(Myo)Fibroblast function

Chemotaxis
produce CT such as collagen Glucoaminoglycans and elastin. Myo can contract

11

What are giant cells and name 3 .

Fused Macrophages with multiple Nuclei
Langhans
Foreign Body
Touton Giant cells

12

Describe appearance of Langhans

Nuclei around edges of cell and seen in TB

13

Describe appearance of Foreign Body type

Randomly arranged- Body phagocytosed so seen in cell or on surface

14

Describe appearance of Touton

Ring toward the center. Lesion where they is high lipid content. Xanthomas and Fat Necrosis. Foam Cells

15

Unwanted Effects of acute inflammation

Fibrosis- impair function
Atrophy
Tissue destruction

16

Granulomatous inflammation

Occurs with hard to eliminate particles

17

What are Epithelioid cells

Modified macrophages which look like Epithelial tissue

18

What do Foreign Body granulomas contain ?

Macrophages , FB gaint cells, Epithelioid cells and fibroblasts
Non antigenic material - Surgical thread

19

What do Hypersensitive or immune granulomas Contain?

Macrophages, L giant Cells, Epithelioid cells , Fibroblasts
Insoluble but antigenic particles
They can occupy parachymal space .

20

What is Chronic Cholecyctitis?

Obstruction by gall stones leads to fibrosis of Gall Bladder wall

21

What is Ulcerative Colitis ?

Superficial Bleeding and inflammation in the Colon rectum

22

What are the causes of Cirrhosis

Chronic viral hepatitis (hepatitis B and C)
Fat accumulating in the liver (nonalcoholic fatty liver disease)