Flashcards in Thrombus and Embolism Deck (12):
is a solid mass formed from the constituents of blood within the vessels or heart during life.
• Changes in Vascular Wall (Endothelial damage) –
• Changes in Blood Flow (Slow or turbulent flow)
• Changes in Blood (Hypercoagulability)
Meadure PT and Extrinsic pathway
• Resolution – Dissolved
• Propagation – Grows
• Organisation – Fibrous Repair , scar
• Recanalisation – New channel through the occlusive thrombus = smaller capacity in new vessel
• Embolization – Breaks off and circulates.
• Occlusion of artery = ischaemia and infraction
• Embolism distant to site of thrombus
• Congestion and oedema in venous bed
• Repeated miscarriages due to Uteroplacental Vasculature = Inherited thrombophilia’s
A solid, liquid or gas carried by blood that impacts vascular lumen.
Pulmonary emboli arise
80 % source of pulmonary = Deep veins of Thigh , popliteal vein
before the bifurcation of artery thus blocking both branches. Mostly in pulmonary artery.
Thromboemboli in arteries
L heart, Aneurysms and thrombi on ulcerated atherosclerosis. They go to lower body, brain, intestines , kidneys, spleen and arms.
In left heart:
• Infracts commonly left. Thrombi can then form on the affected necrotic endothelium in Ventricular Cavity. Heart beat = embolism
• Atrial Fibrillation = decreased contraction. Dilation of Left atrium. Stagnation of blood.
• Vegetations more common
Form in veins but embolise to arteries. They bypass lungs by :
• Small emboli are able to pass through arterio- venous anastomoses in pulmonary circulation
• Larger by Interventricular defects in septum or a patent foramen ovale during coughing , lifting or straining. (pressure in R heart greater than left)
Stroke = more likely to have Patent Foramen Ovale.