CIS

Question 1

Complications of blood transfusions (2)

Answer 1

1. Hepatitis A or B
2. HIV

Question 2

Bone marrow cellularity < ____ %, plts < _____/mm³, reticulocytes < ______/mm³ = very severe aplastic anemia

Answer 2

• 25
• 20,000
• 20,000

Question 3

Advanced HIV tx (2)

Answer 3

1. tx opportunistic infections
2. HAART (20% causes anemia)

(and monitor CD4 count)

Question 4

Risk of doxycycline (for acne vulgaris)

Answer 4

aplastic anemia

Question 5

There are 1 in _____ cases of aplastic anemia in patients with chronic viral hepatitis.

Answer 5

30

Question 6

Causes of spherocytes in the peripheral blood smear include: HS, _____ (4).

Answer 6

1. AIHA
2. Wilson disease
3. Clostridial Septicemia
4. Thermal injury

Question 7

LDH, peripheral blood smear, haptoglobin, serum Hgb, UA, direct coombs test are labs to order if you suspect

Answer 7

AIHA

Question 8

If a patient with HS is in an aplastic crisis, you would give them ______.

Answer 8

blood transfusion

Question 9

Treatment for HS includes a splenectomy and ______.

Answer 9

life-long prophylaxis & pneumococcal vaccination

Question 10

Extrahepatic disorders a/w chronic hepatitis C include, AIHA, ______ (3)

Answer 10

1. cryoglobulinemia
2. B-cell lymphoma
3. ITP

Question 11

MC Leukopenia

Answer 11

neutropenia

Question 12

______ is a congenital cause of neutropenia

Answer 12

Kostmann syndrome

Question 13

MC reason for agranulocytosis is ______.

Answer 13

drug toxicity

Question 14

Lymphopenia is not usually a loss of lymphocytes, but rather a ______.

Answer 14

change in the distribution of lymphocytes

Question 15

2 MC causes of lymphopenia

Answer 15

1. HIV or viral infection
2. malnutrition

(for example, infection = TNF-a will cause T cells to be sequestered to the lymph node)

Question 16

Deep ulcerations in the mouth, skin infections and colony-like lesions (infection) are signs of _____

Answer 16

leukopenia

Question 17

Leukopenia tx (2)

Answer 17

1. G-CSF (aka Filgrastim)
2. broad-spectrum ABX

Question 18

_____(2) are the largest mediating factors for leukocytosis

Answer 18

1. IL-1
2. TNF

(both are released in response to infection to stim immune response)

Question 19

Basophilia (leukocytosis) is commonly seen in _______ disorders

Answer 19

myeloproliferative

Question 20

______ (leukocytosis) seen in chronic infection, bacterial endocarditis,rickettsiosis, or malaria.

Answer 20

monocytosis

Question 21

______ (leukocytosis) is seen in viral infections, bordetella pertussus.

Answer 21

Lymphocytosis

(commonly seen w/monocytosis)

Question 22

Dohle bodies

Answer 22

patches of dilated ER (sky-blue puddles)

(indicates infectious process)

Question 23

Lymphadentitis

Answer 23

inflammatory process → lymphocytes → secondary lymph tissues → germinal center + T cell zone hyperplasia

Question 24

Lymphadenopathy present at the lymph nodes are swollen, gray-red and engorged. Histologically, they exhibit prominent ________ and large______.

Answer 24

• neutrophils w/necrosis (“bag of pus”)
• germinal centers

Question 25

Acute nonspecific lymphadenitis appears in the cervical region during _____ infections. The axillary or inguinal? Mesenteric? (they are enlarged, painful and erythematos)

Answer 25

* teeth; tonsil infections * extremities * appendicitis (systemic viral infection → generalized lymphadenopathy)

Question 26

Chronic nonspecific lymphadenitis will lead to a large oblong germinal center B-cell reaction, called \_\_\_\_\_\_

Answer 26

follicular hyperplasia

Question 27

Paracortical hyperplasia (chronic nonspecific lymphadenopathy)

Answer 27

T-cell reaction → effacement of the follicle (seen in viral infection)

Question 28

Sinus histiocytosis is an increase in number and size of the \_\_\_\_\_\_. This is prominent in \_\_\_\_\_\_.

Answer 28

* lymphatic sinusoids * lymph node draining cancers

Question 29

In acute nonspecific lymphadenitis the lymph nodes are erythematous, painful and enlarged. How does chronic nonspecific lymphadenitis present?

Answer 29

1. Enlarged 2. nontender (common in axillary and inguinal nodes)