Citric acid cycle Flashcards
(45 cards)
What happens in cellular respiration?
Pyrucate is oxidized to H2O and CO2
What is the first step of cellular respiration?
Production of acetyl CoA
Under which conditions is glucose turned into Acetyl CoA?
Aerobic
Under which conditions does the citric acid cycle happen?
Aerobic
What is the second step of the cellular respiration?
Oxidation of acetyl groups to CO2 in the citric acid cycle
What is stage 3 of cellular respiration?
Electron transport chain and oxidative phosphorylation
What is the mitochondrial pyruvate carrier (MPC)?
H+ coupled pyruvate specific symporter
Where is the mitochondrial pyruvate carrier (MPC) found?
Inner mitochondrial membrane
Why is oxygen so important?
To regenerate NAD
Where are the two NAD pools located?
Cytoplasm
Mitochondria
What does the citric acid cycle oxidizes?
Acetyl CoA to CO2 and H2O
Most important allosteric regulartor
ATP and ADP
Different name for citric acid cycle
Krebs cycle
What is the citric acid cycle a source of?
Biosynthetic precursor
What is the fuel for citric acid cycle?
Acetyl CoA
Where does the citric acid cycle take place?
Matrix of mitochondria
What I s substrate channeling?
The passage of intermediates from one enzyme directly to another enzyme without release
What allows lipoamide to move between different active sites?
Flexible linkage
How many steps does the citric acid cycle have?
8
What is the first reaction of the citric acid cycle?
Citrate syntheses (formation of citrate)
What does citrate synthase catalyse?
Condensation of acetyl CoA with oxaloacetate to form citrate
What is the delta G of the first reaction in the citric acid cycle?
Very negative, pretty much irreversible
What kind of fit does citrate synthase exhibit?
Induced fit
What is the reaction intermediate of the first reaction of the citric acid cycle?
Citryl CoA
