Class 10: Learning And Memory Flashcards
Had the breakthrough in human functional brain mapping.
Worked w/ seizure pt.’s
Showed the role of temporal lobe in memory
Dr. Penfield
Explicit memory
Memory of places, events, facts, and people
Temporal lobe
This is lost in dementia.
Declarative memory
Implicit memory
Perceptual motor learning and mental operations - riding a bike
Doesnt depend on a structure of temporal lobe.
Storage = striatum
Procedural memory
CA1 connecting to CA3 via Schaffer’ nerve
Long-term potentiation
Which receptor induces LTP:
NMDA….AMPA also
PKC is activated by:
Ca++
4 monomers-tetrameric
NMDA / AMPA
W/o cytoskelton elements appropriately placed:
AMPA receptors are not going to go where they need to.
Problem w/ trafficking=cytoskeleton error.
The more the neurons fired (more frequency) =
increases LTP
More times you read the same facts, more likely you are to recall.
Long-term req’s constant firing.
Mechanisms of learning:
- can req’ NMDA activation and Ca++ / calmodulin-dependent phosphatase vs. kinase
- can be NMDA independent via metabotrophic glutamate receptors (mGluR)
What are req’d for potentiation:
Continuous firing
Proteins
Potentiation:
Fine tuning post-synaptic side
Ca++ that floods into cell activates one common mediator:
CaMKinase
Smart mice engineering: NR2B is a subunit of NMDA
More expression=more channels to form
Based on playing w/ toys.. Tests amt. of time the mouse played w/ certain toys. Stopped playing w/ orange cup..getting bored and go to the new toy. (Doogie mouse moved onto new toy much faster) bring toys back.. doggie goes to new toy while WT mouse plays w/ both equally
Candidate cellular process for consolidating and storing memory
Synaptic re-entry reinforcement (SRR)
