Classic Labs/Findings 1

Question 1

Anticentromere antibodies

Answer 1

Scleroderma (CREST)

Question 2

Antidesmoglein (epithelial) antibodies

Answer 2

Pemphigus vulgaris (blistering)

Question 3

Anti-GMB antibodies

Answer 3

Goodpasture’s Syndrome (glomerulonephritis and hemoptysis)

Question 4

Antihistone Antibodies

Answer 4

Drug induced SLE (hydrazine, procainaminde, phenytoin, INH)

Question 5

Anti-IgG antibodies

Answer 5

Rheumatoid arthritis (RF Rheumatoid Factor)

Question 6

Antimitochondrial antibodies

Answer 6

Primary Biliary Cirrhosis (female, cholestasis, portal HTN)

Question 7

Antineutrophil Cytoplasmic Antibodies (ANCAs)

Answer 7

C-ANCA (Wegner’s) P-ANCA (Churg Strauss, microscopic polyangitis)

Question 8

Antinuclear Antibodies (ANAs: anti-Smith, and anti-dsDNA)

Answer 8

SLE (type II hypersensitivity)

Question 9

Antiplatelet Antibodies

Answer 9

Idiopathic Thrombocytopenic Purpura

Question 10

Anti-topoisomerase Antibodies

Answer 10

Diffuse system scleroderma

Question 11

Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies

Answer 11

Celiac disease (diarrhea, distention, weight loss)

Question 12

Apple Core lesion on Xray

Answer 12

Colorectal cancer (left sided)

Question 13

Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblasts

Answer 13

Auer rods (AML–especially the promyelocytic type)

Question 14

Bacitracin response

Answer 14

Sensitive: Strep Pyogenes (group A), resistant Step Agalactiae (group B)

Question 15

Bamboo spine on xray

Answer 15

Ankylosing spondylitis (chronic inflammatory arthritis, HLA-B27)

Question 16

Basophilic nuclear remnants in RBCs

Answer 16

Howell Jolly Bodies (due to splenectomy or nonfunctional spleen)

Question 17

Basophilic stippling of RBCs

Answer 17

Lead poisoning or sideroblastic anemia

Question 18

Blood tap on TL

Answer 18

subarachnoid hemorrhage

Question 19

boot shaped heart on xray

Answer 19

Tertralogy of Fallot, RVH

Question 20

branching gram positive rods with sulfur granules

Answer 20

Actinomyces israelii

Question 21

bronchogenic apical lung tumor on imaging

Answer 21

pancoast tumor (can compress sympathetic ganglion and cause Horner’s syndrome)

Question 22

cardiomegaly with apical atrophy

Answer 22

Chagas disease (t. cruzi)

Question 23

Brown tumor of bone

Answer 23

Hyperparathyroidism or osteitis fibrosa cystica (deposited hemosiderin from hemorrhage gives brown color)

Question 24

cellular crescents in bowman’s capsule

Answer 24

rapidly progressive crescentic glomerulonephritis

Question 25

chocolate cyst of ovary

Answer 25

endometriosis (usually bilateral)

Question 26

circular grouping of dark tumor cells surrounding pale neurofibrils

Answer 26

Homer Wright rosettes (neuroblastoma, medulloblastoma retinoblastoma)

Question 27

colonies of mucoid pseudomonas in lungs

Answer 27

cystic fibrosis (autosomal recessive mutation in CFTR resulting in fat soluble vitamin deficiency and mucous plugs)

Question 28

decreased alpha-fetoprotein in amniotic fluid/maternal serum

Answer 28

Down's Syndrome or other chromosomal abnormality

Question 29

degeneration of dorsal column nerves

Answer 29

tabes dorsalis (tertiary syphilis), subacute combined degeneration (dorsal columns and lateral corticospinal both affected)

Question 30

depigmentation of neurons in substantia nigra

Answer 30

Parkinson's Disease (basal ganglia disorder, rigidity, resting tremor, bradykinesia)

Question 31

desquamated epithelium casts in sputum

Answer 31

Curschmann's spirals (bronchial asthma can result in whorled mucous plugs.)

Question 32

disarrayed granulosa cells in eosinophilic fluid

Answer 32

Call-Exner bodies (granulosa-theca cell tumor of the ovary)

Question 33

dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia

Answer 33

Koilocytes (HPV: predisposes to cervical cancer)

Question 34

enlarged cells with intranuclear inclusion bodies

Answer 34

"Owl's eye" appearance of CMV

Question 35

enlarged thyroid cells with ground-glass nuclei

Answer 35

"orphan annie eyes" nuclei (papillary carcinoma of the thyroid)

Question 36

eosinophilic cytoplasmic inclusion in liver cell

Answer 36

Mallory bodies (alcoholic liver disease)

Question 37

eosinophilic cytoplasmic inclusion in never cell

Answer 37

Lewy Body (parkinson's disease)

Question 38

eosinophilic globule in liver

Answer 38

councilman body (toxic or viral hepatitis, yellow fever)

Question 39

eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells

Answer 39

Negrei bodies of rabies

Question 40

extracellular amyloid deposition in gray matter of the brain

Answer 40

senile plaques (Alzheimer's disease)

Question 41

Giant B cells with bilobed nuclei with prominent inclusions

Answer 41

Reed-Sternberg cells (Hodgkin's Lymphoma)

Question 42

glomerulus like structures surrounding vessels in germ cells

Answer 42

schiller-duval bodies (yolk sac tumor)

Question 43

"Crew-cut" appearance on xray

Answer 43

Beta-Thalassemia, sickle cell anemia (marrow expansion)

Question 44

hCG elevated

Answer 44

Choriocarcinoma, hydatidiform mole (occurs with or without embryo)

Question 45

heart nodules (granulomatous)

Answer 45

Aschoff bodies (rheumatic fever)

Question 46

heterphile antibodies

Answer 46

Infectious mono (EBV)

Question 47

hexagonal, double pointed, needle-like crystals in bronchial secretions

Answer 47

bronchial asthma (charcot-leyden crystals; eosinophilic granules)

Question 48

high level of D-dimers

Answer 48

DIC, PE, DVT

Question 49

hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)

Answer 49

Ghon Complex (primary TB)

Question 50

"honeycomb lung" on xray or CT

Answer 50

interstitial pulmonary fibrosis