Classic Labs/Findings Flashcards by R M

Onion skin periosteal reaction

Ewing sarcoma

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Hair on end appearance on xray

Beta-thalessemia, Sickle cell anemia

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Wire loop glomerular capillary appearance on light microscopy

Lupus nephropathy

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Antidesmoglein antibodies

Pemphigus vulgaris

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Decreased AFP in amniotic fluid or maternal serum

Down syndrome

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Thyroid like appearance of kidney

Chronic bacterial pyelonephritis

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Soap bubble in femur or tibia on xray

Giant cell tumor of bone

Generally benign

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Podocyte fusion or effacement on EM

Minimal change disease

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Intranuclear eosinophilic droplet-like bodies

Cowdry Type A bodies (HSV or CMV)

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Rectangular crystal like cytoplasmic inclusions in Leydig cells

Reinke crystals (Leydig cell tumor)

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Lumpy bumpy appearance of glomeruli on IF

PSGN (immune complex deposition of IgG and C3b)

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Glomerulus-like structure surrounding vessel in germ cells

Schiller-Duval bodies (yolk sac tumor)

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Circular grouping of dark tumor cells surrounding pale neurofibrils

Homer-Wright rosettes (neuroblastoma, medulloblastoma, retinoblastoma)

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Optochin response

Sensitive: Strep pneumo

Resistant: Virdans strep

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Anti GBM antibodies

Goodpastures

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Antiplatelet antibodies

Idiopathic thrombocytopenic purpura

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Cardiomegaly with apical atrophy

Chagas disease (Trypanosoma cruzi)

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Giant B cells with bilobed nuclei with prominent inclusions

Reed-Sternberg cells (Hodgkin lymphoma)

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Heterophile antibodies

EBV

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Hilar lymphadenopathy

Peripheral granulomatous lesion in middle or lower lung lobes (Can calcify)

Ghon complex

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Increased uric acid levels

Gout

Lesch-Nyhan syndrome

Tumor lysis

Loop & Thiazide diuretics

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Linear appearance of IgG deposition on glomerular basement membrane

Goodpasture syndrome

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Lytic hole punched bone lesions on xray

Multiple myeloma

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Mucin filled cell with peripheral nucleus

Signet ring (gastric carcinoma)

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RBC casts in urine

Acute glomerulonephritis

Apple core lesion on axr

Colorectal Cancer

Basophilic stippling of RBCs

Lead poisoning or sideroblastic anemia

Bacitracin response

Sensitive: Strep pyogenes (Group A) Resistant: Streptococcus agalactiae (Group B)

Large lysosomal vesicles in phagocytes + immunodeficiency

Chediak-Higashi

Polished ivory-like appearance of bone at cartilage erosion

Eburnation (osteoarthritis resulting in bony sclerosis)

Heart nodules (Granulomatous)

Aschoff bodies (rheumatic fever) ![]()

Antineutrophil cytoplasmic antibodies

MPO-ANCA/p-ANCA: MPA and Churg Strauss c-ANCA/PR-3 Anca: Wegener

Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis

Granulomatosis with Polyangitis (wegener; cANCA) Goodpasture syndrome (anti-GBM antibodies)

Eosinophilic globule in liver

Councilman body (toxic or viral hepatitis, often yellow fever)

Yellowish CSF

Xanthrochromia

Thrombi made of white/red layers

Lines of Zahn (arterial thrombus, layers of platelets/RBCs) ![]()

Renal epithelial casts in urine

Acute toxic/viral renal injury

Protein aggregates in neuron from hyperphosphorylation of tau protein

Neurofibrillary tangles (Alzheimer) and Pick bodies (Pick disease)

High levels of D-dimers

DVT, PE, DIC

Antinuclear antibodies (Anti-Smith, anti-dsDNA)

SLE (type III HS)

Disarrayed granulosa cells in eosinophilic fluid

Call-Exner bodies (Granulosa-Theca cell tumor of ovary)

Antihistone antibodies

Drug-induced SLE (Hydralazine, INH, phenytoin, procainamide)

Antimitochondrial antibodies

Primary Biliary Cirrhosis

WBCs that look smudged

CLL (almost always B cell)

Anti-topoisomerase antibodies

Diffuse systemic scleroderma

Branching gram + rods w/sulfur granules

Actinomyces Israelii

Bloody tap on LP

SAH

Spikes on BM, dome like subepithelial deposits

Membranous glomerulonephritis ![]()

Silver staining spherical aggregation of tau proteins in neurons

Pick bodies ![]()

Azurophilic peroxidase positive granular inclusions in granulocytes and myeloblasts

Auer rods | (AML - especially PML type M3)

Bronchogenic apical lung tumor on imaging

Pancoast tumor

Increased AFP in amniotic fluid/maternal serum

Dating error, anencephaly, spina bifida

Novobiocin response

Sensitive: Staph epidermidis Resistant: Staph saprophyticus

Waxy casts with low urine flow

Chronic ESRD

Elevated hCG

Choriocarcinoma Hydatidiform mole (+/- embryo, multiple pregnancy)

Nodular hyaline deposits in glomeruli

Kimmelstiel-Wilson nodules (diabetic nephropathy)

Dysplastic squamous cervical cells w/nuclear enlargement and hyperchromasia

Koilocytes (HPV)

Thumb sign on lateral xray

Epiglottitis (H Flu)

Brown tumor of bone

Hyperparathyroidism or osteitis fibrosa cystica

Desquamated epithlium casts in sputum

Curschmann spirals (Bronchial asthma - can result in whorled mucus plugs)

Psamomma bodies

1. Meningioma 2. Papillary thyroid carcinoma 3. Mesothelioma 4. Papillary serous carcinoma of endometrium and ovary

Eosinophilic cytoplasmic inclusion in liver cell

Mallory body (alcoholic liver disease)

Narrowing of bowel lumen on barium xray

String sign (Crohn disease)

Lead pipe colon on barium enema

Ulcerative colitis (loss of haustra)

Hexagonal, double-pointed, needle-like crystals in bronchial secretions

Bronchial asthma (Charcot-Leyden crystals: Eosinophilic granules) ![]()

Keratin pearls on skin biopsy

SCC

Iron-containing nodules in alveolar sputum

Ferruginous bodies (asbestosis: Increased chance of mesothelioma)

Enlarged thyroid cells with ground-glass nuceli

Orphan Annie eyes nuclei - papillary carcinoma of thyroid

t[8;14]

Burkitt lymphoma C-myc activation

Depigmentation of neurons in substantia nigra

Parkinson disease

Basophilic nuclear remnants in RBCs

Howell-Jolly bodies (due to splenectomy or nonfunctional spleen)

Pseudopalisading tumor cells on brain biopsy

Glioblastoma multiforme ![]()

Migrating DVTs and vasculitis

Trousseau syndrome - adenocarcinoma of pancreas or lung

Stippled vaginal epithelial cells

Clue cells (Gardnerella vaginalis) ![]()

Periostum raised from bone, creating triangular area

Codman triangle on x-ray (osteosarcoma, Ewing sarcoma, pyogenic osteomyelitis)

Anti-IgG antibodies

Rheumatoid arthritis

Hypochromic microcytic anemia

Iron deficiency anemia Lead poisoning Thalessemia

Eosinophilic cytoplasmic inclusion in nerve cell

Lewy body (Parkinson disease)

Hypertension, HypoK, metabolic alkalosis

Conn syndrome

Mammary gland (blue domed) cyst

Fibrocystic change of breast

Rhomboid crystals, positively birefringent

Pseudogout (calcium pyrophosphate dihydrate crystals)

Trousseau syndrome

Adenocarcinoma of pancreas or lung that causes hypercoaguability

Anticentromere antibodies

CREST Scleroderma

Eosinophilic inclusion bodies in cytoplasm of hippocampal and cerebellar nerve cells

Negri bodies of rabies

Monoclonal antibody spike

* Multiple myeloma * MGUS * Waldenstrom (IgM) * Primary amyloidosis

WBC casts in urine

Pyelonephritis

Tram-track appearance of capillary loops of glomerular basement membranes on light microscopy

Membranoproliferative glomerulonephritis ![]()

Nutmeg appearance of liver

Chronic passive congestion of liver due to RHF

Classic Labs/Findings Flashcards

(88 cards)