Classical Pathway of Complement System Flashcards
1
Q
[C2] and [C4] complexes can be activated by…
A
[C2a+b] & [C4a+b]; C1s (serine protease)
2
Q
C2b and C4b join to form […] and activates […]
A
C3 convertase; C3 protein complex
3
Q
Histamine is released by…
A
Mast cells and basophils that are stimulated by C3a (an anaphylatoxin)
4
Q
C3b acts as…
A
An opsonin - binds covalently to membrane glycoproteins on pathogens and is a beacon for phagocytes
5
Q
C5 activation by […] is also facilitated by…
A
C3 convertase; C3b binding
6
Q
C5a & C5b…
A
An anaphylatoxin and a chemoattractant for neutrophils;
Seeds the formation of membrane attack complex (MAC) via C6, C7 & C8 binding.
7
Q
MAC recruits…
A
Multiple C9 molecules that bind pathogen membrane and lyse target cell.
