Clin path 5: Non-regenerative Anemia

Question 1

Hypoplasia

Answer 1

Decrease in size cells

Question 2

Atrophy

Answer 2

Decrease in cells size

Question 3

Bicytopenia

Answer 3

the reduction of any of the two cell lines of blood

Question 4

Pancytopenia

Answer 4

Deficiency of all three cellular components of the blood (red cells, white cells, and platelets)

Question 5

Myelosuppression

Answer 5

a decrease in bone marrow activity that results in reduced production of blood cells

Question 6

Myelotoxic/Myelotoxin

Answer 6

Toxins that result in a decrease in bone marrow activity that results in reduced production of blood cells

Question 7

Myelophthisis

Answer 7

a form of bone marrow failure due to replacement of hematopoietic tissue by abnormal tissue, most commonly cancer

Question 8

CBC characteristics of non-regenerative anemia

Answer 8

-No reticulocytosis
-No evidence of acute hemorrhage
-No evidence of hemolysis

Question 9

Types marrow hypoplasia

Answer 9

• Selective erythroid hypoplasia
• Generalized marrow hypoplasia

Question 10

Selective Erythroid Hypoplasia

Answer 10

Decrease in only red blood cells

Question 11

Generalized Marrow Hypoplasia

Answer 11

Either Bicytopenia or Pancytopenia

Question 12

Erythropoiesis

Answer 12

the production of red blood cells.

Question 13

Nutrients required for erythropoiesis

Answer 13

Iron, Iron transport proteins, erythropoietin, thyroid hormones

Question 14

Anemia of Nutrient disorders- conditions

Answer 14

(Normocytic, Normochromic)
- Chronic kidney disease: Decreased EPO leads to profound severs anemias
- Chronic blood loss
- Hypothyroidism: establishes base rates for many metabolites.

Question 15

Anemia of chronic disease (ACD)
Anemia of inflammatory Disease (AID)

Characteristics

Answer 15

Severity: Mild to moderate
Cause: almost any disease

Question 16

What causes microcytic normochromic indicies?

Answer 16

• Release of cytokines
• Liver increase production of hepcidin (Neg regulator of iron)
  -Traps iron in macrophages
• Leads microcytic normochromic

Question 17

Iron sequestration molecule in chronic inflammatory disease

Answer 17

Hepcidin

Question 18

Toxic drugs leading to selective erythroid Hypoplasia

Answer 18

Drugs: rhEPO

Question 19

Toxic viruses leading to selective erythroid Hypoplasia

Answer 19

FeLV

Question 20

Idiopathy leading selective erythroid Hypoplasia

Answer 20

Autoantibodies

Question 21

Virus toxin leading to Generalized Marrow Hypoplasia

Answer 21

Viruses: FeLV, parvovirus

Question 22

Bacteria toxin leading to Generalized Marrow Hypoplasia

Answer 22

Ehrlichia (tick-borne)

Question 23

drug toxins leading to Generalized Marrow Hypoplasia

Answer 23

Chemotherapy
Estrogen
Trimethoprim-sulfmethoxazol (TMS)
Methimizole

Question 24

Household toxin leading to Generalized Marrow Hypoplasia

Answer 24

Plants

Question 25

Idiopathy leading to Generalized Marrow Hypoplasia

Answer 25

Autoantibodies

Question 26

what kind of cells does regenerative IMHA attack?

Answer 26

Mature red blood cells

Question 27

what kinda fo cells non-regenerative IMHA attack?

Answer 27

Attacks RBC precursor cells --> selective red cell hypoplasia

Question 28

Causes of myelophthisis

Answer 28

Marrow replacement: - Fungal DX - Radiation therapy - Neoplasia

Question 29

Myelothisis disease leading generalized marrow hypoplasia

Answer 29

- Myelitis - Leukemia - Myelofibrosis