Clinical Aspects of Dementia Flashcards

(53 cards)

1
Q

What is dementia?

A

Progressive global cognitive decline
Irreversible
Associated decline in functioning

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2
Q

Dementia diagnosis rates have increased in Scotland in recent years. TRUE/FALSE?

A

TRUE

  • national push for more patients to get their diagnosis (targets)
  • Diagnosis of Dementia will continue to increase due to ageing population
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3
Q

Prevalence of dementia increases after what age?

A

65 years (this then counts as “older adults”

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4
Q

Why is it important to know how may patients suffer from dementia in Scotland?

A

Helps budget for their care

Larger push towards developing new treatment if more patients suffering

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5
Q

Why is post diagnostic support important after a diagnosis of dementia?

A
  • often a time of uncertainty
  • Advance planning should be encouraged while patients have the capacity
  • counselling may be required
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6
Q

What advance planning mechanisms should be considered when patients are given a dementia diagnosis?

A
  • practical and legal advice (i.e Powers of Attorney, guardianship (if lacking capacity)
  • driving - inform DVLA
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7
Q

Explain why dementia causes strain on the NHS in terms of finances and hospital beds.

A
  • using up to ¼ of hospital beds
  • stay longer in hospital than other
  • 1/3 go into hospital from own homes but are discharged to a care home
  • Supporting people with dementia to leave hospital one week sooner would save least £80 million a year
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8
Q

How is dementia clinically diagnosed?

A
  • Hx consistent with global cognitive decline over months/years
  • Cognitive testing consistent with Hx
  • Decline in level of function
  • No evidence of reversible cause
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9
Q

What cognitive testing is usually offered for patients who present with memory loss?

A

Addenbrookes Cognitive Assessment (ACE-III)
Montreal Cognitive Assessment
Frontal Assessment Battery (FAB)
Detailed neuropsychological testing

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10
Q

How do patients with memory loss usually present to the GP?

A
  • rarely present themself

- usually brought by a spouse OR an older child

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11
Q

What symptoms are first noticed by patients themselves in relation to memory loss?

A

Short term memory loss

Word finding difficulties

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12
Q

What do patients often blame their memory loss symptoms on?

A

Sensory impairments - e.g. poor eyesight, poor hearing

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13
Q

What can potentially affect a patient’s performance in an Addenbrooke’s assessment?

A

Low IQ
Sensory impairment
depression
Anxiety when in clinic

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14
Q

When is the Montreal Cognitive Assessment used?

A

Smaller than addenbrooke’s
=> often used if patient may not be able to tolerate full addenbrooke’s test

  • available in other languages => useful if patient does not use English as first language and requires an interpreter
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15
Q

When would a Frontal Assessment Battery be used?

A

If suspicious of FTD or to test for decline in executive function (as Addenbrooke’s and MoCA dont test these well)

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16
Q

What questionnaire is used to provide a collateral history and compare the patients function NOW to their function 10 years ago?

A

Short IQCODE

16 Qs

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17
Q

What is involved in an OT assessment for Dementia and where is it carried out?

A

Observation of activities- washing, dressing, using a phone, shopping, making toast, travelling.

Carried out in assessment “kitchen” i.e. an unfamiliar environment

Estimates cognitive level and level of supervision required for daily living

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18
Q

Give examples of the reversible causes of cognitive impairment?

A
Delirium
Alcohol
Thyroid/metabolic disorders
Depression
Brain lesion
Neuro infections/inflammation
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19
Q

What is mild cognitive impairment?

A
  • Noticeable cognitive impairment

- Little deterioration of function

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20
Q

How much do patients with a Mild Cognitive Impairment usually score on the ACE-III or MoCA?

A

ACE-III usually 75-90

MoCA usually 24-26

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21
Q

If a patient is found to have mild cognitive impairment, how often should cognitive testing be repeated?

A

Yearly

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22
Q

What is meant by subjective cognitive impairment?

A
  • Patient thinks they are cognitively impaired
  • cognitive testing and function = NORMAL
  • associated with anxiety/depression/stress
  • often have a relative or friend with dementia
  • Vicious cycle of increasing anxiety about memory =>
    causing more memory lapses
23
Q

Who usually refers patients with dementia to old age psychiatry?

A

GP
Medicine for the elderly
Neurology
Other general hospital clinic

24
Q

What should be involved in giving a dementia diagnosis?

A
  • Ask patient if they want to bring relative/friend to appointment
  • Allow adequate time
  • What do they already know? Do they remember cognitive testing?
  • What do they want to know?
  • Clear explanation of condition
  • How do they feel?
  • Address specific concerns - e.g. admission/ nursing home etc
25
What are the main clinical features of Alzheimer's Dementia?
Memory loss particularly short term Dysphasia Dyspraxia Agnosia
26
Scans are not diagnostic, but what may appear on a CT/MRI of a patient with Alzheimer's?
CT/MRI may be normal, | OR medial temporal lobe atrophy or temporoparietal atrophy
27
What variants of Alzheimer's dementia are known to exist?
Frontal | Posterior cortical atrophy
28
What are the main clinical features of vascular dementia?
Dysphasia dyscalculia frontal lobe symptoms affective symptoms more common than in Alzheimers May ALSO have: - focal neurological signs - vascular risk factors - step wise decline
29
What do CT/MRI and SPECT scans usually show in vascular dementia?
CT/MRI = moderate-severe small vessel disease or multiple lacunar infarcts SPECT- patchy reduction in tracer uptake throughout brain
30
What are the 3 main syndromes of Frontotemporal dementia?
Behavioural variant- behavioural changes, executive dysfunction, disinhibition, impulsivity, loss of social skills, Primary progressive aphasia- effortful non-fluent speech, speech sound/articulatory errors, Semantic dementia- impaired understanding of words, fluent but empty speech, difficulty retrieving names
31
How does Frontotemporal dementia appear on CT/MRI or SPECT scans?
CT/MRI- frontotemporal atrophy | SPECT- frontotemporal reduction in tracer uptake
32
What is the criteria for a diagnosis of Dementia with Lewy Bodies?
Early reduced attention, executive function and visuospatial skills AND Two of: - Visual hallucinations - Fluctuating cognition (delirium-like) - REM sleep behaviour disorder - Parkinsonism - Positive DAT scan
33
What is the difference between Dementia with Lewy Bodies and a diagnosis of Parkinson's Disease Dementia?
Must have parkinsonism for at least 1 year prior to onset of dementia => Parkinsons dementia NOT Dementia with Lewy Bodies
34
What imaging may be used in a patient with a suspected dementia?
CT MRI Single Photon Emission CT DaT (Dopamine Active Transporter) Scan
35
CT is used to exclude what organic causes of cognitive decline?
tumour bleed stroke
36
When is MRI typically used to investigate a dementia?
if <70 Fast progression Atypical features
37
What is SPECT useful for?
Differentiating types of dementia | especially Frontotemporal Dementia
38
A DaT scan is used to indicate what types of dementia?
Dementia with Lewy Bodies | Parkinson's Dementia
39
What cholinesterase inhibitor is licensed for the treatment of dementia with Lewy Bodies and Parkinson's dementia?
Rivastigmine
40
What are the usual side effects of cholinesterase inhbitors?
Nausea and diarrhoea | these usually subside after 2 weeks
41
When is memantine used?
Moderate alzheimer's dementia | can be used earlier to prevent further decline
42
Why is it important to monitor BP in memantine use?
Can increase blood pressure
43
Who makes up the informal carers who help dementia patients?
60% spouses | 30% older children
44
What can be used to test if patients with dementia are competent to drive?
- Score >70 on Addenbrookes - Rockwood driving battery (tests divided attention/ visuospatial function) - On road driving test
45
What cholinesterase inhibitors are licensed for use in ALzheimers dementia?
donepezil Rivastigmine Galantamine
46
When are cholinesterase inhibitors contraindicated?
active peptic ulcer | severe asthma/COPD
47
What other function does memantine have other than slowing dementia decline?
prevents behavioural and psychological symptoms
48
What household items can be made more dementia-friendly for patients?
Clock - digital, morning/afternoon etc, reminders to take tablets Phone - large numbers or even photos on phone handset Signposting - made obvious Clear kitchen cupboards GPS
49
What are the most common behavioural and psychological symptoms associated with dementia?
``` Hallucinations/Delusions Insomnia Anxiety Disinhibition Agitation Aggression Depression ```
50
What non-pharmacological management should be used for patients initially in dementia?
``` Review physical symptoms Consider medication side effects sensory aids Environment Activities Exercise Sleep hygiene ```
51
What short term treatments can be used to restore circadian rhythm in dementia patients suffering from insomnia?
melatonin Z drugs benzodiazepines sedating antidepressants
52
What drugs can be used for agitation and aggression in patients with dementia?
``` benzodiazepines antipsychotics sedating antidepressants cholinesterase inhibitors memantine pregabalin ```
53
What drugs can be used for visual hallucinations in dementia?
cholinesterase inhibitors | antipsychotics (BE AWARE OF USING THESE IN LEWY BODY)