Neurobiology of Cognition Flashcards

(48 cards)

1
Q

What functions are thought to be specific to the mind rather than the brain?

A

Higher level thinking:

  • memory
  • judgement
  • social communication
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2
Q

What is Mind-Body dualism?

A

Philosophical view that mind/mental phenomena are non-physical

OR that mind and body are distinct and separable.

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3
Q

What is meant by substance dualism?

A

Philosophical view that two sorts of substances exist: the mental and the physical.

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4
Q

What is known as semantic memory?

A

Remembering factual information

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5
Q

What test can be completed to check that patients with Dementia still have the cognitive ability to drive?

A

Divided Attention Test

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6
Q

What part of driving do patients with dementia often struggle with?

A

Unfamiliar situations
=> procedural memory is usually intact, but they have difficulty reacting when presented with something they weren’t expecting

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7
Q

How did Aristotle first describe a memory?

A

Holding a perceived experience in mind and recognising that you have seen it externally in the past (i.e. it is not an internal thought)

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8
Q

What did Galen propose about the brain?

A

That it was the source of mental activity

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9
Q

Most functions are coordinated by multiple areas of the brain. TRUE/FALSE?

A

TRUE

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10
Q

Where is Broca’s area located?

A

Posterior inferior frontal gyrus

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11
Q

What does a lesion in Broca’s area cause?

A

Broca’s dysphasia - Patient an comprehend others but has difficulty forming words and fluent speech

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12
Q

Where is Wernicke’s area located?

A

Superior Temporal gyrus

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13
Q

What does a lesion in Wernicke’s Area cause?

A

Receptive dysphasia
=> patient can comprehend language
=> speech is fluent, but often does not make much sense as they do not understand what they are saying

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14
Q

What are Brodmann’s Areas and in which area is the Primary Motor Cortex located?

A

cerebral cortex classified into areas by its cyto-architecture
i.e. histological structure and cellular organisation

Primary Motor Cortex = Brodmann’s Area 4

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15
Q

What scan can be used to identify which areas increase in activity during certain tasks?

A

Functional MRI

- shows increase in blood flow in certain areas

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16
Q

Briefly explain the multi-store model of memory

A

Sensory memory -> pay attention to it -> Moves to Short term Memory -> Rehearsal -> Long term Memory

Retrieval of memory from long term to short term -> Recall

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17
Q

How long do memories remain in the short term memory for?

A

between 7 secs to 1 min

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18
Q

What part of the brain is responsible for encoding short term memory to become long term memory?

A

Hippocampus

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19
Q

What is the definition of dementia and what else is required for a diagnosis?

A

Progressive global cognitive decline
IRREVERSIBLE

  • must also be at least mild functional impairment present for diagnosis
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20
Q

If patients have a diagnosis of mild dementia and still wish to carry on with work as normal, what support can be put in place?

A
  • Employment adjustments can be made if patient still has decent function
21
Q

Where does Alzheimer’s usually begin in the brain?

A

Mediotemporal lobes (hence why memory is affected early)

22
Q

What are the most common presenting symptoms of Alzheimer’s?

A

Most common - memory problems

May also have word finding difficulty

23
Q

What 3 symptoms are indicative of Alzheimer’s dementia?

A

Dysphasia
Dyspraxia (lack of coordination)
Agnosia (difficulty identifying objects)

24
Q

Name an end stage symptom of Alzheimer’s dementia

A

Loss of swallow

=> dysphagia

25
What is the average life expectancy after a diagnosis of Alzheimer's?
7 years
26
What are the histological hallmarks of alzheimers dementia?
Amyloid plaques OUTSIDE of cells Neurofibrillary Tangles INSIDE of cells
27
What forms the intracellular neurofibrillary tangles in Alzheimer's dementia?
hyperpolarised Tau protein aggregation
28
Which of the two histological hallmarks of Alzheimer's has a larger link to cognitive impairment?
Neurofibrillary tangles
29
What class of drugs is usually used to treat Alzheimer's disease? Give examples of specific drugs in this class.
Cholinesteras inhibitors => prevents breakdown of ACh => more remains in synaptic cleft e.g. Rivastigmine, Donepezil
30
Memantine is also used to treat Alzheimer's Dementia. What class does this drug belong to and what does it aim to do?
- NMDA receptor antagonist - Previously was only used in moderate -> severe Alzheimer's, but now being started when in Mild -> Moderate phase - Aims to prevent psychosis and other psychiatric symptoms from developing
31
How does Vascular dementia usually appear on a CT scan?
White matter hyperintensities visible
32
What is dyscalculia?
problems with maths/ understanding numbers that develops in certain types of dementia
33
What protein aggregates with Ubiquitin in Lewy Body Dementia?
Alpha-synuclein
34
What other neural pathology occurs in Lewy Body Dementia and what group of symptoms does this result in?
Loss of dopaminergic neurons in substantia nigra | => Parkinsonism symptoms
35
What symptoms of Lewy Body dementia predispose to patients falling?
Fluctuating conscious level Parkinsonism Hypotension Visuospatial problems
36
What drugs should be avoided to treat Lewy Body Dementia and why?
Dopamine agonists - e.g. SINIMET given in Parkinsons - can caused marked abnormal behavioural symptoms - can decrease cognition
37
What drugs are commonly used to treat Lewy Body Dementia?
Cholinesterase inhibitors | Anti-psychotics can also be useful
38
At what age does Fronto-temporal dementia normally start?
55-65 years | => earlier than other dementias
39
What are the main symptoms of Fronto-temporal dementia?
Personality/ behaviour change | - patient becomes disinhibited and has a lack of interest in social acceptance
40
What symptoms are particularly noticeable in the behavioural variant of Fronto-temporal dementia?
Non-fluent aphasia - much like Broca's dysphasia Semantic Dementia - loss of factual understanding/ understanding of words
41
What is Wernicke's encephalopathy?
Collection of neurological symptoms caused by a deficiency in Vitamin B1 Thiamine
42
What are the main 3 symptoms of Wernicke's Encephalopathy
Ataxia Confusion Ophthalmoplegia
43
What other symptoms can patient with Wernicke's Encephalopathy experience?
``` Visual OR Hearing impairment Reduced conscious level Hypothermia Lactic acidosis Circulatory changes ```
44
How is Thiamine replaced in Wernicke's Encephalopathy?
Pabrinex infusion
45
What are the two most common causes of Wernicke's Encephalopathy?
Overconsumption of Alcohol | Lack of thiamine in diet
46
What is Korsakoff's syndrome and what causes it?
Atrophy of mammillary bodies in the brain (affecting memory) Caused by leaving Wernicke's Encephalopathy untreated
47
What symptoms do patients with Korsakoff's syndrome experience?
Antegrade amnesia - inability to learn new information Confabulation Retrograde amnesia - forget events which happened in the past before condition began Telescoping of events - perceive things as more recent than they were
48
What other forms of brain damage can be caused by alcohol?
Myelin sheath degradation Neuroinflammation Subdural Haematoma (if pt falls)