Clopidogrel

Question 1

Pharmacology and presentation of Clopidogrel?

Answer 1

75mg Tablet

Impairs platelet function by antagonizing the binding of ADP to platelets (ADP causes platelet shape change & aggregation)

Question 2

Indicators of Clopidogrel?

Answer 2

• STEMI in conjunction with fibrinolytic therapy

Question 3

Contraindications of Clopidogrel?

Answer 3

• Known severe allergy

Question 4

Cautions of Clopidogrel?

Answer 4

• Clinically significant bleeding.
• At risk of bleeding. (PCI Checklist)
• Pregnancy

Question 5

Side Effects of Clopidogrel?

Answer 5

• Increased bleeding

Question 6

Dosing Regimes of Clopidogrel?

Answer 6

Administered orally once
- 300 mg if the patient is aged less than 75 years.
- 75 mg if the patient is aged greater than or equal to 75 years

Question 7

Onset and duration of Clopidogrel?

Answer 7

Onset:
- 30-60 minutes

Duration
- 3-5 days