Valproate

Question 1

Pharmacology and presentation of Valproate?

Answer 1

400mg powder ampoule

-Anticonvulsant, that predominantly blocks sodium channels but also enhances the activity of GABA at it’s receptors within the central nervous system.

Question 2

Indicators of Valproate?

Answer 2

• Status epilepticus that has not responded to two doses of midazolam

Question 3

Contraindications of Valproate?

Answer 3

• Known severe allergy.

Question 4

Cautions of Valproate?

Answer 4

• None

Question 5

Side Effects of Valproate?

Answer 5

• None

Question 6

Dosing Regimes of Valproate?

Answer 6

Administer IV, dissolve with 4ml of saline, dilute to 10-20ml
- If giving Valproate ICP required

Adult IV
-1200mg IV, once

Paediatric IV or 300mg per 10kg IV once except for 30kg
- 5kg = 150mg IV, once
- 10kg = 300mg IV, once
- 20kg = 600mg IV, once
- 30kg = 800mg IV, once
- 40kg = 1200mg IV, once

Question 7

Onset and duration of Valproate?

Answer 7

Onset:
- 10-20mins

Duration
- 6-12hrs