Clozapine Flashcards
(25 cards)
What is Clozapine primarily used to treat?
Clozapine is primarily used to treat treatment-resistant schizophrenia.
True or False: Clozapine is the first-line treatment for schizophrenia.
False.
What is a significant side effect of Clozapine that requires regular monitoring?
A significant side effect of Clozapine is agranulocytosis, which requires regular blood monitoring.
Fill in the blank: Clozapine is classified as an ________ antipsychotic.
atypical.
What is the mechanism of action of Clozapine?
Clozapine works by antagonizing dopamine D2 and serotonin 5-HT2A receptors.
What is the starting dose of Clozapine for adults?
The starting dose of Clozapine for adults is typically 12.5 mg once or twice daily.
True or False: Clozapine has a lower risk of extrapyramidal symptoms compared to typical antipsychotics.
True.
What is the maximum recommended dose of Clozapine?
The maximum recommended dose of Clozapine is usually 900 mg per day.
What laboratory test is essential before starting Clozapine treatment?
A complete blood count (CBC) is essential before starting Clozapine treatment.
What is the main reason Clozapine is not used as a first-line treatment?
Clozapine is not used as a first-line treatment due to its risk of serious side effects, including agranulocytosis.
Fill in the blank: Clozapine can also be used to reduce the risk of ________ in patients with schizophrenia.
suicide.
What are two common side effects of Clozapine?
Two common side effects of Clozapine are sedation and hypersalivation.
True or False: Clozapine can cause metabolic syndrome.
True.
What should be monitored regularly during Clozapine treatment?
White blood cell counts should be monitored regularly during Clozapine treatment.
What is the brand name of Clozapine?
The brand name of Clozapine is Clozaril.
True or False: Clozapine can be used in combination with other antipsychotics.
False.
What is the risk associated with abrupt discontinuation of Clozapine?
Abrupt discontinuation of Clozapine can lead to withdrawal symptoms and relapse of psychosis.
What is the initial titration schedule for Clozapine?
The initial titration schedule for Clozapine typically involves increasing the dose by 25 mg every 1-2 weeks.
What is a rare but serious side effect of Clozapine?
A rare but serious side effect of Clozapine is myocarditis.
Fill in the blank: Clozapine is particularly effective in patients with ________ schizophrenia.
treatment-resistant.
What is the primary concern with Clozapine therapy that necessitates the Clozapine Risk Evaluation and Mitigation Strategy (REMS)?
The primary concern is the risk of agranulocytosis.
What is the effect of Clozapine on suicidal behavior in patients with schizophrenia?
Clozapine has been shown to reduce suicidal behavior in patients with schizophrenia.
True or False: Clozapine can cause weight gain in some patients.
True.
What should patients be educated about regarding Clozapine and driving?
Patients should be educated that Clozapine may cause sedation and affect their ability to drive.
