CMA prep July

Question 1

how many types of validity are there for animal models

Answer 1

3

Question 2

what are the three types of validity criteria

Answer 2

construct
predictive
face

Question 3

what is construct vailidity

Answer 3

similiar cause or pathophysiology between the human condition and animal model

Question 4

what is predictive validity

Answer 4

treatments that are effective in animal models are also effective in human patients and vice versa

Question 5

what is a translational task

Answer 5

train an animal to mimic a human test

Question 6

what is naturalistic

Answer 6

use a relevant intrinsic or innate skill or preference of the animal

Question 7

how do you measure fear

Answer 7

cued or contextual fear conditioning

Question 8

how do you measure anxiety

Answer 8

elevated plus maze/elevated platform/light-dark maze/open field

Question 9

how do you measure attention

Answer 9

attentional set-shifting task (wisconsin card sort task)

Question 10

how do you measure depression

Answer 10

learned helflness/forced swim

Question 11

how do you measure locomotor activity

Answer 11

activity box/open field

Question 12

how do you measure locomotor coordination

Answer 12

rotarod, skilled reaching, balance beam

Question 13

how do you measure sensory perception

Answer 13

von frey test, temperature sensitivity

Question 14

in fear conditioning what does the amygdala used for

Answer 14

cued fear conditioning

Question 15

what is the combination in amygdala and hippocampus in fear conditioning used for

Answer 15

contextual fear conditioning

Question 16

what is used to measure schizophrenia, ADHD, Autism spectrum, frontotemporal dementia

Answer 16

attention

Question 17

what is attentional set and cognitive flexibility used

Answer 17

rat/mouse must pay attention to either odour of bowl, texture of digging medium or texture of bowl covering and the correct strategy is switched frequently

Question 18

what does the mouse have to choose between in attentional set and cognitive flexibility

Answer 18

food reward is buried
choose by:
odour of bowl contents
texture of bowl contents
texture of bowl outer covering

Question 19

how do you induce depression/apathy/anhedonia

Answer 19

tail suspension test
forced swim test

Question 20

how to measure anhedonia

Answer 20

sucrose preference test

Question 21

how do you measure apathy

Answer 21

sucrose splash test

Question 22

what is used to test for parkinson’s or MND

Answer 22

locomotor activity
(activity box/open field)

Question 23

how do you measure Huntinton’s or MS

Answer 23

locomotor coordination
rotarod, balance beam, skilled reaching

Question 24

how fo you measure pain sensitivity in parkinson’s or chronic pain

Answer 24

sensory/pain perception
von frey test, temperature sensitivity

Question 25

what is used to measure stroke

Answer 25

radial arm maze

Question 26

what are the 3 phases of learning and memory

Answer 26

encoding
storage
retrieval