CML

Question 1

which chromosome is present in more than 95% of patients with chronic myeloid leukaemia (CML

Answer 1

Philadelphia chromosome

Question 2

chronic myeloid leukaemia (CML). It is due to a

Answer 2

Philadelphia chromosome

Translocation between the long arm of chromosome 9 and 22

results in part of the ABL proto-oncogene from chromosome 9 being fused with the BCR gene from chromosome 22. The resulting BCR-ABL gene

BCR-ABL gene codes for a fusion protein that has tyrosine kinase activity in excess of norma

Question 3

CML ONSET ?

Answer 3

60-70 years

Question 4

Presentation of CML

Answer 4

anaemia: lethargy
weight loss and sweating are common
splenomegaly may be marked → abdo discomfort and early satiety

Question 5

blood test in CML

Answer 5

granulocytes at different stages of maturation +/- thrombocytosis = increase band cells
low mature cells

Low leukocyte alkaline phosphate !!!!

Question 6

Management of cml ?

Answer 6

imatinib

is now considered first-line treatment
inhibitor of the tyrosine kinase associated with the BCR-ABL defect

hydroxyurea
interferon-alpha
allogenic bone marrow transplant