Waldenstrom's macroglobulinaemia

Question 1

Waldenstrom’s macroglobulinaemia

Answer 1

characterised by the secretion of a monoclonal IgM paraprotein

usually IgM paraproteinaemia is waldenstorm

Question 2

features of Waldenstrom’s macroglobulinaemia

Answer 2

Organomegaly/ hepatosplenomegaly with no bone lesions

hyperviscosity syndrome e.g. visual disturbance / deep vein thrombosis

unexplained bruising.

lymphadenopathy

cryoglobulinaemia e.g. Raynaud’s

Question 3

investigations of waldenstorm macroglobulinaaemia ?

Answer 3

monoclonal IgM paraproteinaemia

Question 4

Management waldenstrom’s macroglobulinaemia ?

Answer 4

rituximab-based combination chemotherapy