CNS Drugs Flashcards Preview

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Flashcards in CNS Drugs Deck (14):
1

Phenytoin (Dilantin)

Hydantoins (Antiepileptic): selective Na channel inhibition of hyperactive neurons

-Generalized seizures (tonic-clonic)

2

Ethosuximide (Zarontin)

Succinimides: inhibition of Ca influx of hyperactive neurons in thalamus

-Absence seizures

3

Phenobarbital

Barbiturates: stimulates GABA receptors, CNS depressant *

-Tonic-clonic, focal seizures, acute convulsive episodes

*Pregnancy

4

Carbamazepine (Tegretol)*

Suppresses high-frequency neuronal discharge in and around seizure foci

-Epilepsy, bipolar, trigeminal and glossopharyngeal neuralgias

*grapefruit juice, phenytoin, phenobarbital, warfarin, oral contraceptives

5

Valproic acid (Depakote)

Anticonvulsant

6

Gabapentin (Neurontin)

Seizures and nerve damage (diabetic neuropathy)

7

Lorazepam (Ativan)

Benzodiazepines: BZ 1 receptor (sleep), BZ 2 receptor (memory, motor, sensory, cognitive)

8

Diazepam (Valium)

Benzodiazepines: BZ 1 receptor (sleep), BZ 2 receptor (memory, motor, sensory, cognitive)

9

Midazolam (Versed)

Benzodiazepines: BZ 1 receptor (sleep), BZ 2 receptor (memory, motor, sensory, cognitive)

10

Alprazolam (Xanax)

Benzodiazepines: BZ 1 receptor (sleep), BZ 2 receptor (memory, motor, sensory, cognitive)

11

Temazepam (Restoril)

Hypnotic: causes drowsiness and facilitates the onset and maintenance of natural sleep

12

Eszopiclone (Lunesta)

Non-benzodiazepam hypnotic

-Induces sleep quickly, prevents waking up in the middle of night, can be used for long-term use

13

Ramelteon (Rozerem)

Melatonin receptor agonist: high affinity for melatonin receptors, no effect on GABA

-Treatment of chornic insomnia

14

Zolpidem (Ambien)

Rapid onset, does not cause insomnia rebound effect, short term use

-Episodic insomnia