CNS- tricyclic antidepressants Flashcards
1
Q
TA examples
A
Amitriptyline Hydrochloride, Lofepramine, Imipramine Hydrochloride (-ine hydrochloride)
2
Q
TA indications
A
Major depressive disorder, anxiety, migraines, neuropathic pain (MS)(nerve damage)
3
Q
TA MOA
A
Block serotonin/norepinephrine reuptake from synaptic cleft to presynaptic neuron= increased conc and prolonged action of neurotransmitters. Differ from SSRI as TA non-selective (also work on histamine, acetylcholine…)
4
Q
TA side effects
A
Blood pressure fluctuations, blurred vision, urine retention
5
Q
TA cautions
A
serious liver disease, arrhythmias, heart block, bipolar
