Flashcards in CNS tumours (9) Deck (50)
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1
What percentage are CNS tumours of all neoplasms?
2%
2
What's the most common cancer in children?
Leukaemia, then CNS tumours
3
Which CNS tumours are most common in women?
Meningioma
4
Which CNS tumours are most common in men?
Glioma
5
What CNS tumours are most common in children?
Cerebellum, PNET (medulloblastoma)
6
Which CNS tumours are most common in adults?
Cerebrum, glioma and meningioma
7
Function of arachnoid membrane and pia mater
Protein and support
8
Tumour of arachnoid membrane and pia mater
Meningioma
9
Function of neurons
Sit in cortex, cause epilepsy, not in contact with blood supply need quiet environment, don't give origin to many tumours, metabolic needs supplied by glia cells
10
Tumour of neuronal
Neurocytoma
11
Tumour of nerve sheath
Schwannoma
12
Glia cells
Astrocytes, Oligodendrocytes, Ependymal cells and choroid plexus cells, microglia
13
Tumour of glia
Glioma
14
Function of astrocytes
Support and protect (connect neurons with blood supply)
15
Tumour of astrocytes
Astrocytoma
16
Function of oligodendrocytes
Myelination
17
Tumours of oligodendrocytes
Oligodendroglioma
18
Function of ependymal cells
Controls, produces and moves CSF
19
Tumour of ependymal cells
Ependyoma
20
Function of choroid plexus cells
Specialised ependymal cell
21
Function of microglia
Defence (activated if ischaemia, allows inflammatory cells cross BBB)
22
Benign behaviour
Slow growing, respect surrounding tissue, no/slow progression, no recurrence, surgery
23
Malignant behaviour
Rapid growing, invade and destroy surrounding tissue, progress, recurrent, surgery and adjuvant therapy
24
Grade 1
Benign, no recurrence, no/very slow progression
25
Grade 2
Low grade, progression (astrocytoma 6-7 y)
26
Grade 3
High grade, rapid progression (astrocytoma 2-3 y)
27
Grade 4
Aggressive (necrosis and vascular proliferation)
28
Histological criteria for malignancy
1. Cellular density and atypia
2. Mitotic activity
3. Necrosis
4. Vascular proflieration
29
Atypia
Structural abnormality in cell
30
