Flashcards in CNS tumours (9) Deck (50)
What percentage are CNS tumours of all neoplasms?
What's the most common cancer in children?
Leukaemia, then CNS tumours
Which CNS tumours are most common in women?
Which CNS tumours are most common in men?
What CNS tumours are most common in children?
Cerebellum, PNET (medulloblastoma)
Which CNS tumours are most common in adults?
Cerebrum, glioma and meningioma
Function of arachnoid membrane and pia mater
Protein and support
Tumour of arachnoid membrane and pia mater
Function of neurons
Sit in cortex, cause epilepsy, not in contact with blood supply need quiet environment, don't give origin to many tumours, metabolic needs supplied by glia cells
Tumour of neuronal
Tumour of nerve sheath
Astrocytes, Oligodendrocytes, Ependymal cells and choroid plexus cells, microglia
Tumour of glia
Function of astrocytes
Support and protect (connect neurons with blood supply)
Tumour of astrocytes
Function of oligodendrocytes
Tumours of oligodendrocytes
Function of ependymal cells
Controls, produces and moves CSF
Tumour of ependymal cells
Function of choroid plexus cells
Specialised ependymal cell
Function of microglia
Defence (activated if ischaemia, allows inflammatory cells cross BBB)
Slow growing, respect surrounding tissue, no/slow progression, no recurrence, surgery
Rapid growing, invade and destroy surrounding tissue, progress, recurrent, surgery and adjuvant therapy
Benign, no recurrence, no/very slow progression
Low grade, progression (astrocytoma 6-7 y)
High grade, rapid progression (astrocytoma 2-3 y)
Aggressive (necrosis and vascular proliferation)
Histological criteria for malignancy
1. Cellular density and atypia
2. Mitotic activity
4. Vascular proflieration
Structural abnormality in cell