CNS tumours (9) Flashcards Preview

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Flashcards in CNS tumours (9) Deck (50)
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1

What percentage are CNS tumours of all neoplasms?

2%

2

What's the most common cancer in children?

Leukaemia, then CNS tumours

3

Which CNS tumours are most common in women?

Meningioma

4

Which CNS tumours are most common in men?

Glioma

5

What CNS tumours are most common in children?

Cerebellum, PNET (medulloblastoma)

6

Which CNS tumours are most common in adults?

Cerebrum, glioma and meningioma

7

Function of arachnoid membrane and pia mater

Protein and support

8

Tumour of arachnoid membrane and pia mater

Meningioma

9

Function of neurons

Sit in cortex, cause epilepsy, not in contact with blood supply need quiet environment, don't give origin to many tumours, metabolic needs supplied by glia cells

10

Tumour of neuronal

Neurocytoma

11

Tumour of nerve sheath

Schwannoma

12

Glia cells

Astrocytes, Oligodendrocytes, Ependymal cells and choroid plexus cells, microglia

13

Tumour of glia

Glioma

14

Function of astrocytes

Support and protect (connect neurons with blood supply)

15

Tumour of astrocytes

Astrocytoma

16

Function of oligodendrocytes

Myelination

17

Tumours of oligodendrocytes

Oligodendroglioma

18

Function of ependymal cells

Controls, produces and moves CSF

19

Tumour of ependymal cells

Ependyoma

20

Function of choroid plexus cells

Specialised ependymal cell

21

Function of microglia

Defence (activated if ischaemia, allows inflammatory cells cross BBB)

22

Benign behaviour

Slow growing, respect surrounding tissue, no/slow progression, no recurrence, surgery

23

Malignant behaviour

Rapid growing, invade and destroy surrounding tissue, progress, recurrent, surgery and adjuvant therapy

24

Grade 1

Benign, no recurrence, no/very slow progression

25

Grade 2

Low grade, progression (astrocytoma 6-7 y)

26

Grade 3

High grade, rapid progression (astrocytoma 2-3 y)

27

Grade 4

Aggressive (necrosis and vascular proliferation)

28

Histological criteria for malignancy

1. Cellular density and atypia
2. Mitotic activity
3. Necrosis
4. Vascular proflieration

29

Atypia

Structural abnormality in cell

30

Hardest part about treating Gliomas?

Cells migrate through brain, can't see borders/take it out completely, no barriers in communication