Flashcards in coagulation cascade Deck (10)
What test measures the extrinsic pathway and what reagents are used?
-thromboplastin and calcium
What type of anticoagulant effects the extrinsic pathway?
What initiates the extrinsic pathway?
by tissue factor (provides a phospholipid surface not normally found in blood) as it enters the vascular system
What does tissue factor activate?
What does factor VII activate?
factor X (common pathway)
When factor II is activated what does it positively feedback to?
factor XI (intrinsic)
how does the common pathway begin?
activation of factor X
what factors are part of the intrinsic pathway?
12 → 11 → 9 → 10(common)
need 8 for 9 to activate 10
what factors are part of the extrinsic pathway?
3 → 7 → 10