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Flashcards in coagulation cascade Deck (10)
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1

What test measures the extrinsic pathway and what reagents are used?

-pt
-thromboplastin and calcium

2

What type of anticoagulant effects the extrinsic pathway?

coumadin

3

What initiates the extrinsic pathway?

by tissue factor (provides a phospholipid surface not normally found in blood) as it enters the vascular system

4

What does tissue factor activate?

factor VII

5

What does factor VII activate?

factor X (common pathway)

6

When factor II is activated what does it positively feedback to?

factor XI (intrinsic)

7

how does the common pathway begin?

activation of factor X

8

what factors are part of the intrinsic pathway?

12 → 11 → 9 → 10(common)
need 8 for 9 to activate 10

9

what factors are part of the extrinsic pathway?

3 → 7 → 10

10

what factors are part of the common pathway?

10-5-2-1-13