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Flashcards in intro. to secondary hemostasis Deck (33)
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1

Where are the coagulation factors active/inactive and what is their overall purpose?

Coagulation proteins (Factors)
-Blood – inactive state
-Once activated – interact to form fibrin clot
-Purpose – to reinforce the plt plug

2

Where are the coagulation factors produced?

All factors are produced in the liver

3

What is the name for factor I?

Fibrinogen

4

What is the name for factor II?

prothrombin

5

What is the name for factor III?

Tissue factor or tissue thromboplastin

6

What is the name for factor IV?

Ionized calcium

7

What is the name for factor V?

Labile factor or proaccelerin

8

What is the name for factor VII?

-stable factor (Serum prothrombin conversion accelerator SPCA),
- proconvertin

9

What is the name for factor VIII?

antihemophilic factor

10

What is the name for factor IX?

Christmas factor, plasma thromboplastin component, or antihemophilia factor B

11

What is the name for factor X?

Stuart-Prower factor

12

What is the name of factor XI?

plasma thromboplastin antecedent

13

What is the name of factor XII?

hageman factor or contact factor

14

What is the name of factor XIII?

fibrin stabilizing factor

15

What is another name for Fitzgerald factor?

high molecular weight kinogen

16

What is another name for Fletcher factor?

prekalikrein

17

Which factor is the main substrate?

Fibrinogen

18

Which factors are cofactors?

-Factor V (labile factor)
-VIII:C (antihemophilic factor (AHF))

19

Which factors are serine proteases?

Serine proteases – cut peptide bonds
Includes all except XIII (IIa,VIIa, IXa, Xa, XIa, XIIa, prekallikrein)

20

Which factor is a transaminase?

XIIIa-creates cross-links to stabilize clots

21

Which factors are contact proteins?

XII – Hageman factor
XI – plasma thromboplastin antecedent
Prekallikrein – Fletcher factor
High-molecular weight kininogen (HMWK) – Fitzgerald factor

22

Which factors are vitamin k dependent?

2, 7, 9, 10

23

Which vitamin k dependent factor has the shortest half life?

7 & is most sensitive levels of coumarin therapy

24

What are the vit. K dep. Inhibitors?

Prot. C & S

25

what do Vit K deficient patients-have decreased production of ?

functional prothrombin proteins
& inhibitors

26

what do Coumarin, Coumadin, Warfarin inhibit?

Vit. K reduction yielding inactive factors

27

what test monitors coumadin therapy?

pt

28

what are Acquired Vit K deficiencies – common, seen in ?

-post surgical procedures
-high dose antibiotic use
-liver disease

29

which factors are Fibrinogen or Thrombin sensitive proteins

I
V
VIII:C
XIII

30

Which group does thrombin act on?

all the factors in the fibrinogen group
-Enhances activity of factors V & VIII:C
-Activates factor XIII
-Converts fibrinogen to fibrin