Flashcards in intro. to secondary hemostasis Deck (33)
Where are the coagulation factors active/inactive and what is their overall purpose?
Coagulation proteins (Factors)
-Blood – inactive state
-Once activated – interact to form fibrin clot
-Purpose – to reinforce the plt plug
Where are the coagulation factors produced?
All factors are produced in the liver
What is the name for factor I?
What is the name for factor II?
What is the name for factor III?
Tissue factor or tissue thromboplastin
What is the name for factor IV?
What is the name for factor V?
Labile factor or proaccelerin
What is the name for factor VII?
-stable factor (Serum prothrombin conversion accelerator SPCA),
What is the name for factor VIII?
What is the name for factor IX?
Christmas factor, plasma thromboplastin component, or antihemophilia factor B
What is the name for factor X?
What is the name of factor XI?
plasma thromboplastin antecedent
What is the name of factor XII?
hageman factor or contact factor
What is the name of factor XIII?
fibrin stabilizing factor
What is another name for Fitzgerald factor?
high molecular weight kinogen
What is another name for Fletcher factor?
Which factor is the main substrate?
Which factors are cofactors?
-Factor V (labile factor)
-VIII:C (antihemophilic factor (AHF))
Which factors are serine proteases?
Serine proteases – cut peptide bonds
Includes all except XIII (IIa,VIIa, IXa, Xa, XIa, XIIa, prekallikrein)
Which factor is a transaminase?
XIIIa-creates cross-links to stabilize clots
Which factors are contact proteins?
XII – Hageman factor
XI – plasma thromboplastin antecedent
Prekallikrein – Fletcher factor
High-molecular weight kininogen (HMWK) – Fitzgerald factor
Which factors are vitamin k dependent?
2, 7, 9, 10
Which vitamin k dependent factor has the shortest half life?
7 & is most sensitive levels of coumarin therapy
What are the vit. K dep. Inhibitors?
Prot. C & S
what do Vit K deficient patients-have decreased production of ?
functional prothrombin proteins
what do Coumarin, Coumadin, Warfarin inhibit?
Vit. K reduction yielding inactive factors
what test monitors coumadin therapy?
what are Acquired Vit K deficiencies – common, seen in ?
-post surgical procedures
-high dose antibiotic use
which factors are Fibrinogen or Thrombin sensitive proteins