coagulation cascade and BBB

Question 1

where does warfarin work?

Answer 1

the vitamin K dependent stages of the coagulation cascade - 2,7,9,10

Question 2

where does heparin work?

Answer 2

activates anti-thrombin so prevents formation of thrombin

Question 3

what are the pathways of the coagulation cascade?

Answer 3

intrinsic and extrinsic

Question 4

intrinsic coagulation cascade

Answer 4

XII to XIIa
XI to XIa
IX to IXa
IXa turns X to Xa

Question 5

extrinsic coagulation cascade

Answer 5

trauma causes VII to VIIa

trauma causes tissue factor to convert VIIa to X > Xa

Question 6

shared coagulation pathway

Answer 6

Xa to Va
Prothrombin (II) to thrombin (IIa)
fibrinogen (I) to fibrin (Ia)

Question 7

what makes up nuclei in the brain?

Answer 7

nerve cell bodies

Question 8

Agnosia

Answer 8

inability to recognise objects, faces, smells or sound

Question 9

apraxia

Answer 9

difficulty with planning and motor activities

Question 10

what makes up basal ganglia?

Answer 10

caudate nucleus
globus pallidus
putamen

Question 11

function of basal ganglia

Answer 11

movements

physical expression

Question 12

what is the BBB

Answer 12

highly selective dynamic and functional neurovascular barrier that restricts the diffusion of water soluble substances from the blood to the brain

Question 13

what does the BBB do?

Answer 13

maintains CNS homeostasis and limits entry of substances the could alter or harm neuronal functions

Question 14

what is the BBB made up of ?

Answer 14

capillary endothelium 
basement membrane 
astrocytes
pericytes
neurons
extracellular matrix