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PMCOL 305 > cocaine > Flashcards

cocaine Flashcards

1
Q

what are the three consumable forms of cocaine

A

coca laves
cocaine hydrochloride
free base cocaine - crack

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2
Q

what is the bioavilability of snorted cocaine

A

70%

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3
Q

what does dissolution of snorted cocaine create

A

HCl

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4
Q

how long is the onset for snorted cocaine

A

3-5 min

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5
Q

how long is the duration of snorted cocaine

A

30-40

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6
Q

what is the onset free base smoke

A

6-10 seconds

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7
Q

what is the duration of inhaled free-base

A

5-30

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8
Q

why can’t u smoke cocaine

A

it pyrolizes before it vaporizes

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9
Q

what temp does crack vapourize at

A

98 celcius

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10
Q

what is the onset of injected cocaine

A

10-15 second

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11
Q

what is the duration of injected cocaine

A

10-20

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12
Q

what is the major metabolite of cocaine

A

benzoylecgonine

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13
Q

what do liver and plasma esterases generate

A

ecgonine methylester

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14
Q

what is created by cocaine when co-administered with alcohol ?

A

cocaethylene metabolites

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15
Q

half life of cocaine

A

12 hr `

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16
Q

what percentage of metabolism is done by non-enzymatic hydrolysis

A

40%

17
Q

which area of the brain can a high dose of cocaine affects

A

medulla

18
Q

which NT underlies sympathiomimetic effects

A

NE

19
Q

cocaethylene is a vaso__-

A

constrictor

20
Q

what does benzos do with respect to cocaine

A

decrease NT release to assist with cardio

21
Q

what does niutroglycerine do with respect to cocaine

A

NO release vasoconstrictive

22
Q

IV treatment with ___ can elimiate cocaine

A

butrylcholinesterase

23
Q

what signaling is chainged by cocaine use

A

opioidergic signaling`

24
Q

what are the 3 treatments for cocaine

A

benzos, nitroglycerine,ice bath, butyrlcholinesterase

PMCOL 305 (19 decks)

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