ecstasy Flashcards
(36 cards)
where was MDMA first synthezised and by whom and when
1912, Merck, Kollish
who first published testing of MDMA. where and when
1960, DOW chemicals, Alexander Shulgin
where can MDMA be extracted from?
ocotea pretiosa
sassafras albidum
cinnamomum parthenoxylon
how must safrole does sassafras essential oile contrain
75-85%
how does ecstacy have a shifted stimulant effect
methylenedioxy ring
where is MDMA distributed
brain lungs liver spleen kidney
how long is the onset for MDMA
30-45 min
what is the TI for MDMA
14-16
what is the half life of MDMA`
6 hours
how long does the high last for MDMA
2-3 hours
how is MDMA degraded & how much of it is degraded in this way
cyp2D6 80%
how is MDMA excreted
kidney 20%
what are the sympathomimetic effects of MDMA
increased heart rate and hyperthermia and diaphoreiss
MDMA actions at which receptor cause bruxism and increased locomotion
5HT1B/2 agonist
how does MDMA reverse 5HT transporters
trace amino associated receptor-mediated phosphorylation
how does MDMA act at NE and DA transporters
blocks them
where is 5HT released after taking MDMA
NAc and VTA
where is DA released after taking MDMA
NAc
blocking which receptor will inhibit 5HT release
5HT2B
what are the 3 other chemicals that MDMA increases
DA, cortisol, prolactin/oxytocin
what is the shift in brain activity after taking MDMA
ventral striatum not amygdala
actions at which receptors cause the sympathomimetic effects of MDMA
adrenergic
actions at which receptors cause hyperthermia
adrenergic
actions at which receptors cause ACh release
histamine type I
