COCCIDIAN Flashcards
(22 cards)
Class of Coccidians
Class Sporozoea
Coccidian parasites infect the __________ ________ of animal
intestinal tracts
The largest group of apicomplexan protozoa
COCCIDIANS
In ________, _____________ and __________________ only a single direct cycle of transmission occurs, both the asexual and sexual stages of multiplication occurs in a single host and that is to ______.
Isospora
Cyclospora
Cryptosporidium
man
In ____________ and ___________, the sexual stages are usually in the intestinal mucosa of a _______________ host (the predator)
Sarcocystis
Toxoplasma
carnivorous
-cosmopolitan distribution
-seropositive prevalence rates vary
-generally causes very benign disease in immunocompetent adults tissue cyst forming coccidia
Toxoplasma gondii
what is the definitive host of toxoplasma gondii
felines
infects wide range of _________ and ____________ (intermediate hosts)
birds and mammals
has been coined for the first, actively multiplying merozoites that develop within the intermediate host, irrespective of whether infection is from oocysts or tissue cysts
Tachyzoites
what is the non infectious and infectious merozoites that develop within tissue cysts.
Metrocytes (noninfectious)
Bradyzoites (infectious)
-ingestion of oocysts
-sporozoites penetrate intestinal epithelium
-rapid intracellular replication (any cell)
-dissemination via macrophages
TACHYZOITE STAGE
-dormant, slowly replicatng
due to host immune response
-chronic or latent infection
-tissue cysts primarily in brain and muscle
Bradyzoite stage
The organisms can grown in any organs or tissues, developing in the _________, ___________ and __________________
brain, eyes, and skeletal muscle
most of the cases are _____________
asymptomatic
diagnosis: to detect antibodies
serological test
diagnosis: very sensitive and specific but requires maintenance of live organism
sabin-feldman methylene blue dye test
detection of the parasites DNA
polymerase chain reaction (PCR)
controls toxoplasma but do not kill it
Pyrimethamine and Sulfadiazine
pyrimethamine can cause lower blood counts
Leucovorin (folic acid)
causes allergic reaction but can be substituted by clindamycin
Sulfadiazine
prevent occurence of hypersensitivity
corticosteroids
prophylaxis for immunocompromised
trimethroprim-sulfamethoxazole