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Flashcards in Coeliac Deck (5)
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1

Definition & cause of coeliac disease

T-cell-mediated autoimmune disease (HLA DQ2) of small bowel

Reaction to gliadin (a prolamin (gluten protein) found in wheat)

Causing villous atrophy & malabsorption

 

2

Outline the typical presentation of coeliac disease

  • Any age (peak - infancy and 50-60yrs)
  • Stinking stools/ steatorrhoea
  • Diarrhoea & weight loss
    • Failure to thrive
  • Bloating abdo pain
  • Nausea & vomiting
  • Aphthous ulcers

3

How do you diagnose coeliac disease?

  • Antibody
    • a-gliadin
    • Transglutaminase
    • Anti-endomysial (IgA antibodies)
  • Endoscopy & duodenal biopsy
    • Villous atrophy
    • WBCs & crypt hyperplasia
  • Reverses on gluten free diet

4

Outline the treatment of coeliac disease

  • Lifelong gluten free diet

5

Outline complications of coeliac disease

  • Anaemia
  • 2ndary lactose intolerance
  • Malignancy