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Rats > Common rat strains and research uses > Flashcards

Common rat strains and research uses Flashcards

1
Q

ACI

A
  • High incidence of urogenital congenital malformations including renal agenesis, hypoplasia, hydronephrosis or cystic kidney, unilateral, that may be associated with ipsilateral defective uterine horn or testis
  • High incidence of testicular tumors
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2
Q

BB/Wor

A
  • Type I DM: juvenile onset
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3
Q

BN

A

Brown Norway

  • Transplantation research: inducible, transplantable myeloid leukemia, bladder carcinoma
  • Hydronephrosis
  • Genetic mapping, respiratory inflammation, immunological dysfunction, aging
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4
Q

BUF

A

Buffalo Rat

  • Spontaneous autoimmune thyroiditis
  • Carcinogenesis & oncology - host for transplantable Morris hepatoma
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5
Q

COP

A

Copenhagen Rat

  • Carcinogenesis research & oncology
  • Protate adenocarcinoma
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6
Q

F-344

A

Fischer 344

  • Inbred rat model for National Toxicology Programs Carcinogen Bioassay Program and the National Institute of Aging
  • General multipurpose model, aging, safety and efficacy testing, surgical model, oncology, nutrition
  • High rate of spontaneous cancer
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7
Q

LEW

A

Lewis Rat

  • Multiple sclerosis & various experimentally induced autoimmune diseases
    • Induced arthritis/inflammation
    • Experimental allergic encephalitis
  • STZ-induced diabetes
  • Transplantation research
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8
Q

LOU/C

A
  • High incidence of myeloma/plasmacytoma
  • Production of IgG autoantibody
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9
Q

SHR

What is the control for this rat?

A

Spontaneous Hypertensive Rat –> WKY is the control strain in studies using SHR

  • Hypertension & CV research: genetic hypertension, hypertensive drug research
  • ADHD model, safety and efficacy testing
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10
Q

WF

A

Wistar-Furth

  • Mononuclear cell leukemia
  • Resistant to chronic renal disease
  • Macrothrombocytopenia model
  • Oncology & carcinogenesis
  • Grand mal seizure
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11
Q

ZDF

A

Zucker Diabetic Fatty

  • Obese, type II DM & metabolic syndrome
    • Obesity
    • Insulin resistance (hyperinsulinemia)
    • Glucose intolerance (hyperglycemia)
    • Dyslipidemia (hypertriglyceridemia, hypercholesterolemia)
    • Hypertension
  • Nephropathy, impaired wound healing, & neuropathy
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12
Q

Battleboro

A
  • Diabetes insipidus
    • autosomal recessive
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13
Q

Gunn

A
  • Jaundice & kernicterus (bilirubin-induced brain injury)
    • Lacks UDP glucuronyl transferase in liver
  • Model of Crigler-Najjar Syndrome
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14
Q

RNU

What is the genotype & phenotype?

A

Rowett Nude Rat…aka…Nude Rat, Athymic Rat

  • Genotype = Foxn1rnu / Foxn1rnu
  • Phenotype = T cell-deficient, B cells & NK cells are present
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15
Q

SHROB

A

Spontaneously Hypertensive Obese Rat

  • Metabolic Syndrome
    • Hypertension
    • Insulin resistance
    • Glucose intolerance
    • Obesity
    • Hyperlipidemia: Type 4 hyperlipoproteinemia
  • Nephropathy
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16
Q

GK (Goto-Kakizaki)

A
  • Non-obese type 2 DM
  • Wistar substrain that develops adult onset DM early in life
17
Q

Zucker

A

Obesity & metabolic syndrome

18
Q

Dahl/SS

What is the control for this rat?

A

Dahl/Salt Sensitive Rat

The SS-13BN is the normotensive control for the Dahl/SS rat

  • Hypertension
  • Diastolic heart failure
  • Nephropathy

.

19
Q

FHH

A

Fawn hooded rat

  • Hypertension & pulmonary hypertension
  • Nephropathy
  • Alcohol consumption
20
Q

LEC

A

Long Evans Cinnamon

  • Model of spontaneous hepatitis and liver cancer d/t abnormal copper metabolism
  • Wilson’s Disease
21
Q

WAG/Rij Rat

A

Wistar Albino Glaxo Rat

  • Bilateral retinal degeneration resembles human retinitis pigmentosa
  • L4415 leukaemia in the WAG/Rij is an animal model for the human acute lymphocytic leukaemia
22
Q

Spotted lethal mutant

A
  • Aganglionic megacolon
  • Model of Hirschsprungs Disease in humans
    • Similar to Lethal White Syndrome most common in American Paint Horses
  • The coat is completely white (unpigmented) except for a pigmented spot on head
23
Q

LES & LE-bo

A

Long Evans Shaker & Long Evans Bouncer

Models of dysmyelination

Prone to seizures which can cause hyperflexion of spine leading to acute hindlimb paralysis

LE-bo presents earlier & has a shorter lifespan

24
Q

WBN/Kob

A

Wistar Bonn Kobori

Type I diabetic rats that spontaneously develop diabetic peripheral motor neuropathy

Rats (4 decks)

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