COMPLEMENT SYSTEM

Question 1

Complement is a complex of more than:

Answer 1

30 SOLUBLE AND CELL-BOUND PROTEINS

Question 2

Who gave the termed “complement”

Answer 2

PAUL EHRLICH IN 1980

Question 3

Acute phase reactants was primarily produced within 12-24 hours by

Answer 3

HEPATOCYTES

Question 4

Increase in certain intracellular signaling polypeptides are called:

Answer 4

CYTOKINES

Question 5

Most plasma complement proteins are synthesized in

Answer 5

LIVER

Question 6

Plasma Complement proteins are released in

Answer 6

ZYMOGENS

Question 7

Complement Activation promotes (3)

Answer 7

ACTIVATION OF IMMUNE SYSTEM

OPSONIZATION

LYSIS OF FOREIGN CELLS AND IMMUNE COMPLEXES

Question 8

Who awarded for elucidating the nature of complement

Answer 8

JULES BORDET

Question 9

Which classical pathway is produced by epithelial cells and factor D

Answer 9

C 1

Question 10

Alternative pathway or Properdin is stabilized by

Answer 10

C3 CONVERTASE

Question 11

STAGES OF OS COMPLEMENT ACTIVATION CLASSICAL PATHWAY

Answer 11

RECOGNITION STAGE

ACTIVATION STAGE

FORMATION OF MAC

Question 12

First complement component to bind is

Answer 12

C1

Question 13

SUBUNITS OF C1

Answer 13

C1q
C1s
C1 r

Question 14

Which subunit of C1, generate enzyme activity to begin the casscade

Answer 14

C1 r & C1s

Question 15

C1 q form:

Answer 15

6 GLOBULAR HEADS WITH COLLAGEN TAIL LIKE PORTION

Question 16

End product in activation stage:

Answer 16

C5 CONVERTASE

Question 17

C2 at least bound c1s at

Answer 17

60nm RADIUS

Question 18

Which component is next to be activated

Answer 18

C2

Question 19

C2 a binds to c4 b to form:

Answer 19

C3 CONVERTASE

Question 20

This complex is not very stable

Answer 20

C3 CONVERTASE

Question 21

Half life of C3 convertase

Answer 21

15 secs to 3 mins

Question 22

C4 at least bound C1 s at

Answer 22

40nm

Question 23

C7 binds to C5b6 to form:

Answer 23

C5b67

Question 24

C8 binds to C5b67 to form:

Answer 24

C5b678

Question 25

C9 binds to C5b678 to form:

Answer 25

COMPLETE LYSIS OF CELL

Question 26

What is the relation between Factor B and C2

Answer 26

THEY ARE ANALOGOUS TO EACH OTHER

Question 27

Who described alternative pathway

Answer 27

PILLEMER IN 1950

Question 28

Proteins in alternative pathway (3)

Answer 28

PROPERDIN FACTOR B FACTOR D

Question 29

Considered as an acute phase protein

Answer 29

MANNOSE-BINDING LECTIN

Question 30

Major constituent of lectin pathway

Answer 30

MANNOSE

Question 31

What are the MBL serine proteases (3)

Answer 31

MASP-1 MASP-2 MASP-3

Question 32

Which MBL pathway cleaves C4 and C2

Answer 32

MASP-2

Question 33

ASSOCIATED DISEASE IN MBL

Answer 33

SEPSIS NEISSERIA INFECTIONS

Question 34

Associated disease in DAF and MIRL

Answer 34

PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

Question 35

Acts as a co factor with 1 to inactivate C4b

Answer 35

C4- BINDING PROTEIN

Question 36

DAF stands for

Answer 36

DECAY ACCELERATING FACTOR

Question 37

MIRL stands for

Answer 37

Membrane inhibitor reactive lysis

Question 38

Complement fixation immunoglobulins (2)

Answer 38

IgG IgM