Complications1-Table 1 Flashcards Preview

OB > Complications1-Table 1 > Flashcards

Flashcards in Complications1-Table 1 Deck (312)
Loading flashcards...
1

What causes physiologic anemia?

Normal changes in ratio of plasma to RBC volume

2

How is physiologic anemia reflected?

As decreased Hct d/t the dilutional effect relative to each trimester

3

What are lab findings associated with Iron def anemia?

decreased Hct

4

What finding may accompany iron def anemia?

PICA

5

How is iron def anemia tx in preggo people?

Add an additional 60-80mg elemental iron daily

6

Why it taking folate a good idea?

Reduce the risk of NTD

7

How much dietary folate should be taken in?

400-800 mcg or 0.4-0.8mg

8

How much folate is in a prenatal vitamin?

1mg, 1000mcg

9

What would indicate a need to increase daily folate to 4mg or 4000mcg daily?

-multifetal gestation
- mom on anticonvulsants
-past hx of NTD pregnancy

10

What are hemoglobinopathies?

heterogeneous group of single gene disorders that include structural Hb variants

11

What is the Hb variant in sickle cell?

Hb A replaced with Hb S

12

What is sickle cell dz?

Homozygotes HbSS
Unstable sickled shape to RBC
Increased viscosity and hemolysis
Decreased oxygenation

13

What is sickle cell trait?

Heterozygoutes Hb AS
Asymptomatic

14

What is isoimmunization?

Formation of maternal antibodies, aka maternal alloimmunization

15

What leads to hemolytic dz of the newborn?

Binding of maternal antibodies to fetal RBC antigens

16

What is hemolytic dz of the newborn characterized by?

Hemolysis, bili relsease, anemia

17

How is the severity of hemolytic dz of the newborn determined?

- how much antibody was produces
- how strongly antibody binds to antigen
- ability of the fetus to replenish the destroyed RBC

18

What are the 4 major blood groups determined by?

Presence or absence of A & B RBC surface antigens

19

What makes group A?

has A antigen on RBCs & B antibody in plasma

20

What makes group B?

has B antigen on RBCs & A antibody in plasma

21

What makes group AB?

has both A & B antigens on RBCs but neither A nor B antibody in plasma

22

What makes group O?

has neither A nor B antigens on RBCs but both A & B antibodies in plasma

23

What is the 3rd antigen? When is it a problem?

Rh (rhesus) factor
Either present + or absent –
Positive is ok, negative is an issue unless both mom and dad are negative

24

What is the Rh system composed of?

A complex of 5 antigens
C, c, D, E, e

25

What is the most common antigen? Hint its part of the Rh- CDE system

Antigen D

26

What is the deal with antigen D?

Present: Rh-D positive
Absent: Rh-D negative

27

Why is antigen D important?

There is isoimmunization potential when an Rh-D negative woman is preggo with a fetus that is positive!

28

How much Rh-D blood is sufficient to cause isoimmunization?

29

How does this work?

Maternal antibodies pass to baby via placenta and cause an antibody response that destroys fetal RBC

30

Is isoimmunization with Rh a concern with 1st pregnant?

Not really- first pregnancy is exposure to mom and second is when the fetus is typically attacked
Gets progressively worse with each subsequent pregnancy