CONGENITAL NEUTROPHIL ABNORMALITIES

Question 1

A GROUP OF DISORDER OF OXIDATIVE METABOLISM AFFECTING THE CASCADE OF EVENTS REQUIRED FOR H2O2 PRODUCTION OF PHAGOCYTES

• affects the neurtophil microbial action
• impairment of NADPH production

Answer 1

chronic granulomatous disease

Question 2

positive result of chronic granulomatus disease

Answer 2

blue precipitate

Question 3

rpresents a qualitative disorder of neutrophils

• rare familial disorder
• neutrophils a giant granules

Answer 3

chediak higashi sydrome

Question 4

most common neeutrophil abnormality

• deficinet of myeloperoxidase
• mild to moderate defect in bacterial killing
• maked defect in fungal killing in vitro

Answer 4

myeloperoxidase deficiency

Question 5

associated poor neutrphil function

Answer 5

diabetes mellitus

Question 6

abnormaities in the cemotactic movement

Answer 6

lazy leukocyte syndrome

job’s syndrom

Question 7

a rare ondition inherited as an autosomal recessive trait.

-LEUKOCYTE ADHESION DEFICIENCY

Answer 7

COMPLMENT RECEPTOR 3 DEFICIENCY

Question 8

ATTACKS INVADERS INSIDE THECELLS

Answer 8

CELL MEDIATED

Question 9

ATTACKS INVADERS OUTSIDE THE CELLS

Answer 9

HUMORAL

Question 10

TYPES OF ADAPTIVE IMMUNITY: (4)

Answer 10

-NATURALLY ACQUIRED ACTIVE IMMUNITY
ARTIFICIALLY ACQUIRED ACTIVE IMMUNITY
NATURALLY ACQUIRED PASSIVE IMMUNITY
ARTIFICIALLY ACQUIRED PASSIVE IMMUNITY

Question 11

SITE OF MATURATION OF t-CELLS AND B CELLS

very active central lymphoid organs amd thymus

Answer 11

primary lymphoid organs

Question 12

site of proliferation and differentiation of t cells and b cells

• peripherall lymphoid organ, platelets, spleen, thymus, GALT
• traappning sites and bystanders of T&B cells
• site of phagoctosis, lymphokines

Answer 12

secondary lymphoid organs

Question 13

whatt are the primary lymphoid organs

Answer 13

bone marrow and thymus

Question 14

secondary lymphoid organs (5)

Answer 14

lymph nodes
tonsils
appendix
peyer's pached
adenoi

Question 15

chief lymphocytes in blood and lymph

Answer 15

t cells

Question 16

marker of t cells

Answer 16

terminal deoxynucleotidyl transferase (TDT)

Question 17

CD$ - regulatory

CD*

Answer 17

effector

Question 18

t cell subsets

Answer 18

t helper cells (CD4)
T suppressor cells (CD8)
T cytotoxic cells (IL@)
T delayed hypersensitivity

Question 19

t cells developments. enumerate

Answer 19

-double negative
double positive
mature t cells 
activated te cells
sensitized t cells
t cell receptor

Question 20

precursor of lymphocyte

Answer 20

thymocyte

Question 21

starting of t cells

Answer 21

CD4 and CD8

Question 22

CD4- and CD8-

Answer 22

double negativ: thymocytes

Question 23

CD4 and CD8+

Answer 23

double positive

Question 24

either CD4 or CD8 is positive
-CD4+ = MHC&raquo_space;?
CD8+ MHC class?

Answer 24

mature t cells
class 2
class 1

Question 25

tcells binds to IL-1

Answer 25

activated t cells

Question 26

t cells that secrete lymphokines

Answer 26

sensitized te cells

Question 27

sheep RBC receptor

Answer 27

CD2

Question 28

part of t cell Ag- receptor complex

Answer 28

CD3

Question 29

classical t cell marker

Answer 29

CD2

Question 30

receptor of MHC class 2 molecule (Th)

Answer 30

CD4

Question 31

receptor of MHC class 2 molecule (Ts and Tc)

Answer 31

CD8

Question 32

receptor of IL-2

Answer 32

CD25

Question 33

receptor of pro b cell

Answer 33

CD19 and CD45

Question 34

receptor for EBV

Answer 34

CD2

Question 35

receptor for b cells

Answer 35

surface immunoglobulin (SmIg)

Question 36

they help b cell to develop into antibody-producing plasma cells

Answer 36

CD4

Question 37

they help CD* cells to become activated cytotoxic tcells

Answer 37

CD4

Question 38

they help macrophages effect delayed hypersensitivity

Answer 38

CD4

Question 39

help activate cytotoxic t cells

Answer 39

Th 1

Question 40

perform the B cell helper function

Answer 40

Th2

Question 41

precursor cell in Ab production

Answer 41

b cells

Question 42

primary follicles and red pulp of spleen

Answer 42

b cells

Question 43

what are the the b cells development

Answer 43

-pro b cells -pre b cells -immature b cells mature b cells -activated b cells -plasma cells

Question 44

successful rearrangements of heavy chains

Answer 44

pre b cells

Question 45

markers of pro b cells

Answer 45

CD19, CD45R CD43 CD24

Question 46

synthesis of the heavy chain part of the antibody molecule | -surrogate light chain

Answer 46

pre b cells

Question 47

completion of light chain rearrangement commits

Answer 47

immature b cells

Question 48

surface proteins of immature b cells

Answer 48

CD2 CD40 MHC class 2 molecule

Question 49

IgM and IgD is present on the surface

Answer 49

Mature b cells

Question 50

exhibit identiffying marers that include CD25, which is found on both activatedde T and B cells and acts as a receptor fr interleukin-2

Answer 50

activated b cells

Question 51

antibody production

Answer 51

plasma cells

Question 52

activated by saller amounts of antigen and require less costimulation tha do naive, unactivated t cells

Answer 52

memory cells