HISTORY OF IMMUNOLOGY

Question 1

Host’s reactions when foreign substances are introduced in the body.

Answer 1

IMMUNOLOGY

Question 2

Foreign substance that induces such an immune response.

Answer 2

ANTIGEN

Question 3

Condition of being resistant to infection.

Answer 3

IMMUNITY

Question 4

Who and what year recorded that individual who previously contracted the disease recovered and recognized their “immune” status?

Answer 4

THUCYDIDES 430 BC

Question 5

Who and what year developed inhaling smallpox scabs in order to produce protection…?

Answer 5

CHINESE 1500S

Question 6

who made the theory and what was the theory that if a healthy individual was exposed as a child or young adult, the effects of the disease would be minimized? they also inject small pox blister

Answer 6

VARIOLATION

Question 7

Published his monumental work on vaccination

Answer 7

EDWARD JENNER

Question 8

he discovered a remarkable relationship between exposure to cowpox and immunity to smallpox

Answer 8

EDWARD JENNER

Question 9

father of immunology

Answer 9

LOUIS PASTEUR

Question 10

the first attenuated vaccine discovered

Answer 10

CHICKEN CHOLERA

Question 11

who applied the same principle to the prevention of rabies

Answer 11

LOUIS PASTEUR

Question 12

who discovered phagocytosis?

Answer 12

ELIE METCHNIKOFF (late 1800s)

Question 13

who proposed humoral theory of immunity? (2 people)

Answer 13

Von Behring, Kitasata

Question 14

Non cellular elements in the blood were responsible for protection from microorganisms

Answer 14

HUMORAL IMMUNITY

Question 15

what are the non-cellular elements?

Answer 15

ANTIBODIES and CYTOKINES

Question 16

who demonstrated the cutaneous (delayed type) hypersensitivity?

Answer 16

KOCH

Question 17

discovered the Complement resulted from his studies on experimental cholera infections in guinea pig “ALEXIN”

Answer 17

PFEIFFER

Question 18

confirms the experiment of pfeiffer and describe immune hemolysis following the mixture of RBCs with specific antibody and alexin

Answer 18

BORDET

Question 19

• he proposed complement
• antibody formation theory
• he was the first to use quantitative measurements of immune reactions

Answer 19

EHRLICH

Question 20

formulated the complement fixation test (2 persons)

Answer 20

BORDET AND GENGOU

Question 21

Provided evidence that the immune reaction could be damaging as well as beneficial by showing anaphylaxis to be an immunologic reaction.

Answer 21

RICHET & PORTIER

Question 22

ARTHUS REACTION OF INTERMEDIATE HYPERSENSITIVITY

Answer 22

ARTHUS

Question 23

showed that diseases of the skin, heart, jints, blood vessels and kidneys, as well as fever could be caused by body’s immunologic reaction to foreign proteins.

Answer 23

von pirquet

Question 24

who linked the two theories by sowing that the immune response involved both cellular and humoral elements?

Answer 24

ALMOTH WRIGHT

Question 25

demonstrated that acquired immunity resulted from both humoral and cellular elements described opsonization.

Answer 25

WHITE AND DOUGLAS

Question 26

what is the Greek word from antigen and its meaning?

Answer 26

gennan: to produce

Question 27

used to describe the agent that conferred immunity on the host by the production of specific antibody.

Answer 27

ANTIGEN

Question 28

who reported the immunologic basis of certain kinds of allergy

Answer 28

PRAUSNITZ AND KUSTNER

Question 29

Who discovered penicillin?

Answer 29

ALEXANDER FLEMMING

Question 30

Who had precised chemical methods for measurement of antigen and antibodies through precipitin analysis

Answer 30

HEIDELBERGER

Question 31

Who developed prontosil?

Answer 31

GERHARD DOMAGK

Question 32

who hypothesis of antigen-antibody binding

Answer 32

MARRACK

Question 33

showed interest in transplantation....

Answer 33

MEDAWAR

Question 34

WHO DEVELOPED THE POLIO VACCINE

Answer 34

SALK, SALBIN

Question 35

WHO DEVELOPED THE VACCINE AGAINST THE YELLOW FEVER

Answer 35

REED

Question 36

IMMUNOELECTROPHORESIS

Answer 36

GRABAR & WILLIAMS

Question 37

- CLONAL SELECTION THEORY | - INTERFERON

Answer 37

BURNET

Question 38

- STUDIED IMMUNODEFICIENCY AND STRUCTURE FUNCTION RELATIONSHIP IN THE LYMPHOID - AS A RESULT OF THE DISCOVERY OF HYPOGAMMAGLOBULINEMIA

Answer 38

BURTON

Question 39

HLA

Answer 39

HUMAN LEUKOCYTE ANTIGENS

Question 40

WHAT YEAR DISCOVERED THAT T CELL AND B CELL COOPERATION IN IMMUNE RESPONSE

Answer 40

1964-1968

Question 41

Th1 and Th2 model of T helper cells. explain the two

Answer 41

Th1 - T cells; killer cells | Th2 - B cells; helper cells

Question 42

who discovered that MHC was important in the regulation of the immune response during antigen presntation?

Answer 42

SCHWARTZ

Question 43

MHC 1

Answer 43

CD8

Question 44

MHC 2

Answer 44

CD4

Question 45

who developed the human papillomavirus?

Answer 45

FRAZER

Question 46

who dveloped the small pox virus?

Answer 46

JENNER

Question 47

phagocytosis

Answer 47

HAECKEL

Question 48

PASTEUR

Answer 48

live, attenuated chicken cholera and anthrax

Question 49

cellulartheory of immunity through phagocytosis

Answer 49

METcHNIKOFF

Question 50

who developed therapeutic vaccination?

Answer 50

pasteur

Question 51

vaccine against yellow fever

Answer 51

REED