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Flashcards in Connective Deck (29):
0

Type IV collagen proteins

Laminin and fibronectin

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Structure of ground substance

Hydrated gel, proteoglycans with GAGs bound to hyaluronan

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Structure of GAG

Glycosaminoglycans - disaccharides covalently bound to core proteoglycan (like bristle brush)

3

Characteristics of loose CT

Lots of cells, lots of ground substance, few fibers, IRREGULAR

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Characteristics of dense CT

Fewer cells, less ground substance, more fibers, more organization

5

Location of mucous CT

Only in embryonic/fetal in umbilical cord

6

Functions of adipose tissue (5)

Padding, insulation, energy, endocrine (leptin), heat production (brown)

7

White vs brown fat

Unilocular vs multilocular (foamy), brown more vascular, more mitochondria

8

Locations of macrophages

Live in connective tissue - ie kupffer in liver, Langerhans in skin, osteoclasts in bone

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Development of macrophages

Bone marrow -> blood (monocytes) -> migrate into tissue

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Types of wandering CT cells

Macrophages, mast cells, plasma cells, leukocytes

11

Characteristics of mononuclear and macrophage cells

Phagocytosis, lots of lysosomes, antigen presentation

12

Mast cell physiology

IgE, causes degranulation of metachromatic -> histamine and immune reaction

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Development of plasma cell

B cell that is activated to produce and antibody

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Appearance of plasma cell

Nucleus to one side (eccentric), large Golgi and rough ER (basophilic), "clock faced nucleus" dt lots of heterochromatin

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Origin of CT cells

Mesenchyme (pluripotential cells), most mesoderm but not all

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Function of fibroblasts

Produce ECM, remodel and repair, not generally active after development

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Appearance of fibroblasts

Small, dense nucleus, no cytoplasm, surrounded by collagen

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Active vs inactive fibroblast

Active has cytoplasm, processes, rough ER, is actively producing ECM

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Type I collagen

Most abundant, visible fibers, dermis, tendons, ECM, bone, ligaments

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Type II collagen

Cartilage, smaller fibers

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Type III collagen

Reticular fibers, in organ stroma

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Type IV collagen

Basement membranes, lacy

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Formation of collagen

In cell - hydroxylization, glycoslyation, form triple helix (procollagen)
Outside cell - cleavage of peptides (tropocollagen), form into fibrils and fiber

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Appearance of collagen fibers

Striped due to gaps between molecules

25

Connection of Vitamin C to collagen

Required for hydroxylization and lysine oxidation

26

Diseases of collagen

Ehlers-Danlos, scury, osteogenesis imperfecta

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Structure of elastin fibers

Elastin surrounded by fibrillin microfibrils

28

Marfan syndrome

Fibrillin deficiency, causes bone and joint stretching, aortic problems, eye problems