Connective Tissue Lesion Neural

Question 1

Part of a neuron

Receive signals from other neuron cells

Answer 1

Dendrites

Question 2

Part of a neuron

Contains the cell nucleus

Answer 2

Cell body

Question 3

Part of a neuron

Conducts electrical impulses along the neuron cell

Answer 3

Axon

Question 4

Part of a neuron

Insulates the axon to help protect the neuron cell and speed up transmission of electrical impulses

Answer 4

Myelin sheath

Question 5

Part of a neuron

Transmits electrical and chemical signals to other neuron cells and effector cells

Answer 5

Axon terminal

Question 6

Etiology of traumatic neuromas

Answer 6

From tooth extraction, local anesthesia injection, from accident

Question 7

Most common location of traumatic neuroma

Answer 7

Mental foramen

Palate - if soft tissue location

Question 8

Microscopically, bundles of nerves in a haphazard or tortuous arrangement are found admixed with dense collagenous fibrous tissue

Answer 8

Traumatic neuroma

Question 9

Treatment for traumatic neuroma

Answer 9

Surgical excision

No recurrence

Question 10

Clinical features of traumatic lesion

Answer 10

50% cases are associated with pain

Radiating facial pain

Wide age range, mostly seen in adults

Question 11

Is traumatic neuroma encapsulated?

Answer 11

Yes = good prognosis

Question 12

Benign neoplasm that is derived from a proliferation of Schwann cells of the neurilemma or nerve sheath

Answer 12

Schwannoma

Question 13

Capable of regeneration

Prerequisite for regenrating neurons of the PNS

The nerve is pushed aside (does not entangle within the tumor)

Answer 13

Schwannoma (neurilemmoma)

Question 14

Encapsulated mass, asymptomatic lump in any age

Tongue = favored location

40S% occur in head and neck

Answer 14

Schwannoma

Question 15

Well defined radiolucent pattern with a corticated periphery and may cause pain or pasthesia

Answer 15

Schwannoma

Question 16

Encapsulated tumor, spindle cells with two different pattern. Antoni A and Antoni B

Answer 16

Schwannoma

Question 17

IHC immunoprofile of schwannoma

Answer 17

S-100

Negative for actin and desmin

Question 18

Consists of spindle cell organized in palisaded whorls and waves

Often surround an acellular eosinophilic zone (verocay body)

Representing reduplicated basement membrane and cytoplasmic cellular processes

Answer 18

Antoni A of schwannoma

Question 19

Consists of spindle cells haphazardly distributed in a delicate fibrillar microcystic matrix

Answer 19

Antoni B Of schwannoma

Question 20

Hypercellular
Nuclear palisading
Whorls and waves
Verocay bodies

Answer 20

Antoni A

Question 21

Hypocelular
Loosely arranged
Haphazard
Myxoid background

Answer 21

Antoni B

Question 22

Essential diagnostic criteria of schwannoma (neurilemmoma)

Answer 22

Hypecellular spindled areas and loose hypocellular myxoid bodies

Spindle cells with buckled, elongated, fusiform nuclei, palisaded

S-100, SOX10 positive

Question 23

Treatment for schwannoma

Answer 23

Surgical excision

Good prognosis - encapsulated

Question 24

May appear as solitary lesion or as multiple lesions as part of the neurofibromatosis (von recklinghausen’s disease of skin)

Answer 24

Neurofibroma

Question 25

An inherited autosomal-dominant trait that has two subsets: one associated with NF1 gene and the other with the NF2 gene

Answer 25

Neurfibroma

Question 26

Cell of origin of: Schwannoma Neurofibroma Mucosal neuroma PEN

Answer 26

Schwann cell Schwann cell and perineural fibroblast Nerve tissue, hamartoma Schwann cell

Question 27

Age Schwannoma Neurofibroma Mucosal neuroma PEN

Answer 27

Any Any Children, young adults Adults

Question 28

Site Schwannoma Neurofibroma Mucosal neuroma PEN

Answer 28

Any, especially tongue Any, especially tongue, buccal mucosa Tongue, lip, buccal mucosa Palate, lip

Question 29

Number Schwannoma Neurofibroma Mucosal neuroma PEN

Answer 29

Solitary Solitary to multiple Multiple Solitary

Question 30

Bone lesions Schwannoma Neurofibroma Mucosal neuroma PEN

Answer 30

Occasionally Frequently No No

Question 31

Syndrome associated Schwannoma Neurofibroma Mucosal neuroma PEN

Answer 31

Neurofibromatosis Neurofibromatosis MEN III None

Question 32

Malignant potential Schwannoma Neurofibroma Mucosal neuroma PEN

Answer 32

Rarely with sydrome Infrequently with syndrome No No

Question 33

clinical features of neurofibroma

Answer 33

Asymptomatic submucosal mass (neoplastic) Unencapsulated Tongue, buccal mucosa and vestibule - most commonly affected NF1: multiple neurofibroma. Cafe-au-lait, bone abnormalities, CNS changes

Question 34

Histopath Non-encapsulatd Random distribution o spindle cells in myxoid to collagenous stroma Nuclei are wavy and tapered

Answer 34

Neurofibroma

Question 35

IHC of neurofibroma

Answer 35

S-100, SOX10, CD34

Question 36

Contains the genetic material of the neuron cell

Answer 36

Nucleus