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Oral Path 2 Finals > Muscular Lesions > Flashcards

Muscular Lesions Flashcards

(50 cards)

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1
Q

A muscular reactive lesion

A

Myositis ossificans

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2
Q

Location of myositis ossificans

A

Sternocleidomastoid, masster

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3
Q

Muscular lesion in neoplasm origin

A

Leiomyoma/leiomyosarcoma

Rhabdomyoma/rhabdomyosarcoma

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4
Q

IHC profile for skeletal lesions

A

+ myogenin , myoglobin , desmin

  • smooth muscle actin , calponin
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5
Q

IHC profile for smooth muscle lesion

A

+ desmin , smooth muscle actin , calponin

  • myogenin , myoglobin
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6
Q

Location of leiomyoma/sarcoma

A

Non-specific, blood vessels

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7
Q

Location of rhabdomyoma/sarcoma

A

Floor of the mouth , soft palate , tongue , buccal mucosa , masticatory muscle

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8
Q

Uncommon reactive lesion of skeletal muscle

A

Myositis ossificans

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9
Q

Myositis ossificans is an ____ inflammatory process in which ossification occurs

A

Intramuscular

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10
Q

Two forms of myositis ossificans

A

Progressive systemic disease ( myositis ossificans progresiva )

Focal single - muscle disorder ( traumatic myositis ossificans )

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11
Q

Etiology of Progressive systemic disease ( myositis ossificans progresiva )

A

Unknown cause

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12
Q

Etiology of Focal single - muscle disorder ( traumatic myositis ossificans )

A

Acute or chronic trauma

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13
Q

Most common location of myositis ossificans in the head and neck region

A

Sternocleidomastoid and masseter

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14
Q

Radiographic feature of myositis ossificans

A

Delicate feathery opacification

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15
Q

Essential diagnostic feature of myositis ossificans

A

Maturation and organization of the osseous tissue peripheral to the central cellular zone

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16
Q

Treatment for myositis ossificans

A

Surgical excision

Little tendency to recur

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17
Q

Most common arise from leiomyosarcoma

A

In the retroperitoneum, mesentery, omentum or subcutaneous and in deep tisues of the limbs

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18
Q

Most common arise of leiomyomas

A

Muscularis layer of the gut and in the body of the uterus

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19
Q

Presents as slow-groing, asymptomatic subucosal masses

Usually in the tongue, hard palate or buccal mucosa

Sinonasal tract, mandible

Any age

A

Leiomyomas

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20
Q

Subtype of leiomyoma

A

Angioleiomyoma (vascular leiomyoma)

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21
Q

Treatment for leiomyomas

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A

Surgically excised, recurrence is unexpected

22
Q

A small cytoplasmic filament, about 5nm in diameter that has contractile properties

23
Q

Treatment for leiomyosarcomas

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A

Wide surgical excision + chemo/radio

Distant metastasis to lungs (50%)

24
Q

Clinical features of leiomyoma

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A

Soft tissue swelling

1% leiomyoma are located in H&N
- 12-15% are angioleiomyomas

M=F predilection

25
20% 5-year survival rate
Leiomyosarcoma
26
50% of case, distant metastasis to lungs
Leiomyosarcoma
27
Bland, spindled tumor cells are arranged in intersecting fascicles. Cells are oval to elongated with cigar-shaped nuclei, without atypia. Mitoses are absent to sparse
Leiomyoma
28
Histopathological feature of leiomyoma
Bland, spindled tumor cells are arranged in intersecting fascicles. Cells are oval to elongated with cigar-shaped nuclei, without atypia. Mitoses are absent to sparse
29
Histopathological features of angioleiomyoma
Prominent vasculature surrounded by smooth muscle cells associated with vessels
30
Prominent vasculature surrounded by smooth muscle cells associated with vessels
Angioleiomyoma
31
IHC profile for leiomyoma
Desmin HMB45
32
Essential diagnostic rieria of leiomyosarcoma or angioS
Fascicles of eosinophilic spindled cells with blunt ended nuclei with variable pleomorphism and mitoses
33
Fascicles of eosinophilic spindled cells with blunt ended nuclei with variable pleomorphism and mitoses
Leiomyosarcoma / angiosarcoma
34
Localization of rhabdomyoma
Momuth and soft tissues of the neck Parapharyngeal space, salivary glands, larynx
35
Two types of rhabdomyoma
Adult type (ARM) Fetal typee (FRM)
36
Age and gender predilection for the two types of rhabdomyoma
ARM - 60yo , M:F = 3:1 FRM - 4.5-60yo , M:F = 5:1
37
Histopathological features of rhabdomyoma For ARM and FRM
ARM: large polygonal cells having abundant eosinophilic, granular or vacuolated cytoplasm (spider cells) with focal cross striation or crystalline (rod-like or jack straw like) inclusion FRM: primitive round to spindle cells and myotube-like rhabdomyoblasts with eosinophilic cytoplasm and cross-striations set in a myxoid matrix
38
IHC for rhabdomyoma
Myogenin Desmin Myoglobin
39
Treatment for rhabdoymyoma
Complete excision No metastasis
40
Subtype of rhabdomyosarcoma thatt occurs in children
Embryonal and alveolar
41
Histopathological feature Primitive round to spindle cells, with scant cytoplasm and hyper chromatic nuclei, scattered rhabdomyoblasts
Embryonal rhabdomyosarcoma
42
Histopathological feature Fibrovascular septa separating cellular nests of small sized monomorphic round cells with scant cytoplasm, rhabdoid
Alveolar rhabdomyosarcoma
43
Histopathological feature Fasciculated proliferation of spindle cells with elongated nuclei and pale indistinct cytoplasm, with interspersed spindled or polygonal rhabdomyoblasts with abundant, brightly eosinophilic cytoplasm
Spindle rhabdomyosarcoma
44
Treatment for rhabdomyosarcoma
Surgical excision, chemo/radio Most adult patients are stage IV at presentation RMS poor prognosis (40-45% 5-year survival rate)
45
Subtype of rhabdomyosarcoma that has an excellent prognosis
Spindle ell and botryoid type
46
When it occurs in the head and neck region, it is typically seen in children. When it occurs outside, it is typically seen in adults
Rhabdomyosarcoma
47
Rapidly growing mass that may cause pain or paresthesia if jaw involvement ocurs.
Rhabdomyosarcoma
48
The most common subtype of rhabdoymyosarcoma
Embryonal type
49
IHC for rhabdoymosarcoma
Desmin , acting , myogenin , myoD1
50
Two consistent and reproducible chromosome translocation that is associated with alveolar rhabdomyosarcoma
T(12:13) (q35;q14) And T(1:13)(p36q14) - less common These translocation juxtapose the PAX3 or PAX7 gene on chromosomes 2 and 1

Oral Path 2 Finals (9 decks)

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