Connective Tissue Lesions Flashcards Preview

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Flashcards in Connective Tissue Lesions Deck (43):
1

What does lymphangioma look like?

Vesicle like if superficial Can appear submucosal when deeper.

2

Leiomyoma Characteristics

Benign tumor of smooth muscles Rare in oral cavity Any age and slow growing

3

Congenital Epulis predilection

BIG female predilection

4

Neurofibroma DDx

Submucosal nodules Traumatic fibroma Granular cell tumor Lipoma Macroglossia Lymphangioma Amyloidosis Myxedema Acromegaly

5

Granular Cell Tumors Histo

Sheet of large cells with granular eosinophilc cytoplasm Pseudoepitheliomatous hyperplasia Granular cells stain with S-100

6

Schwannoma Appearance

Slow growing and submucosal Common locations → tongue, palate, lips NO PAIN, unless compressing a nerve

7

Schwannoma Histo

Interestingly, no nerve tissue in the lesion. As lesion grows, nerve is pushed aside. Antoni Type A and Type B patterns Type A: LOOOOONG spindle shaped cells; paralleling and palisading Type B: MIcrocystic arrangement of cells

8

Traumatic neuromas are associated with pain what percentage

50% Tenderness to severe pain.

9

MEN characteristics

Autosomal dominant MEN 1 and MEN 2A/B MEN 2B has mucosal neuromas (only one with ORAL manifestations) and medullary carcinoma of thyroid gland

10

Cause of traumatic neuroma

Injury to a peripheral nerve that causes inflammation and scarring to the area.

11

DDx Congenital Epulis

Gingival cyst Neuroectodermal tumor of infancy Rhabdomyosarcoma

12

Origin of neurofibroma

Benign tumor of nerve tissue origin

13

Rhabdomyosarcoma Characteristics

Most common malignant neoplasm of skeletal muscles origin 40% occur in the head and neck Common in children (1st decade)

14

Traumatic Neuroma Characteristics

Not a TRUE neoplasm Occurs with trauma, but also cases without trauma present

15

Myositis Ossificans histo

Central proliferating osteoblasts Maturation and organized osseous structures

16

What is this

Q image thumb

Granular cell tumor

17

Cause of MEN

Mutation on RET oncogene Leads to neoplasms arising in endocrine tissues

18

TX Congenital Epulis

Excision

19

What neoplasms involved with MEN

Parathyroid hyperplasia or
adenoma

Multiple pheochromocytomas

Medullary carcinomas of the thyroid
 

20

Neurofibromatosis histo

Composed of Schwann cells, fibroblasts, perineural cells Positive for S-100

21

DDx Granular Cell Tumors

Neurofibroma Schwannoma Fibroma Lipoma

22

Traumatic Neuroma TX

Excision

23

When do mucosal neuromas of MEN occur

Usually early in life

24

Traumatic Neuroma Histo

Nerve fibers in discrete bundles

25

What is cystic hygroma

Lymphangioma of the neck. Large swelling that can be life threatening

26

Neurofibromatosis Appearance

Multiple nodules on skin. 25% of NF will have nodules in the mouth

27

Where lymphangioma occur

The tongue most commonly

28

Schwannoma etiology

Benign neoplasm of Schwann cells of the neural sheath

29

Congenital Epulis Appearance

Usually present at birth Present on the anterior maxilla alveolar crest commonly, Also on mandible (alveolar crest)

30

What bone changes are involved with neurofibromatosis?

Blunderbuss IA canal 

Cortical erosion or intrameduallary erosion

31

Granular Cell Tumors Appearance

Can have a yellowish surface color Usually a single, submucosal mass

32

Location of neurofibroma

tongue, buccal mucosa, palate, vestibule If on tongue, macroglossia possible

33

Myositis Ossificans Characteristics

Reaction lesion of skeletal muscles with intramuscular inflammation with ossification Two forms: progressive systemic and focal single `

34

what is this 

Q image thumb

congenital epulis 

35

Congenital Epulis Histo

Similar to granular cell tumor, but NO pseudoepitheliomatous hyperplasia

36

Lipoma Characteristics

Benign tumor of mature fat

37

Appearance of neurofibroma

Firm nodule that will be color of normal mucosa

38

Oral involvement of MEN 2B

Mucosal neuromas Appear as small, discrete nodules on the labia, larynx, and tongue, BM

39

Another name for congenital epulis

congenital gingival granular cell tumor

40

Cause if neurofibromatosis

An autosomal dominant inherited disease

41

What enlargements can occur with lymphangioma

Macroglossia and macrocheilia

42

Leiomyoma appearance

Firm nodule with normal mucosa

43

Characteristics of neurofibromatosis

Cafe-au-lait spots Well-defined border (Coast of California) Multiple neurofibromas Lisch nodules in eyes Axillary frecking Skeletal deformities