Constipation/Diarrhea

Question 1

medical conditions that cause constipation

Answer 1

IBS, anal disorders, MS, CV events, PD, spinal cord tumors, diabetes, hypOthyroidism

Question 2

nondrug tx for constipation

Answer 2

inc fluids, limit caffiene and alcohol, inc physical activity, inc fiber

Question 3

what drugs cause constipation

Answer 3

antacids, antidiarrheals, clonidine, colesevelam, anticholinergics, iron, non dhp CCBs, opioids, sucralfate

Question 4

pts should be refered to physician if constipation persists after how many days of OTC tx

Answer 4

7 days

Question 5

bulk forming drugs

Answer 5

psyllium (fiber)

Question 6

drug of choice for constipation in pregnancy

Answer 6

psyllium (fiber)

Question 7

osmotics

Answer 7

PEG, magnesium hydroxide, glycerin, lactulose

Question 8

stimulants

Answer 8

senna, bisocodyl

Question 9

drug of choice for opioid induced constipation

Answer 9

stimulants (senna, bisocodyl) or osmotic

Question 10

stool softener

Answer 10

docusate

Question 11

lubricants

Answer 11

mineral oil

Question 12

metamucil

Answer 12

psyllium

Question 13

dulcolax

Answer 13

bisacodyl

Question 14

colace

Answer 14

docusate

Question 15

drug of choice for constipation with straining

Answer 15

stool softeners (docusate, senna)

Question 16

mineral oil contraindications

Answer 16

<6y, pregnant, bedridden, elderly, difficulty swallowing

Question 17

lubiprostone moa

Answer 17

chloride channel activator

Question 18

lubiprostone contraindication

Answer 18

mechanical bowel obstruction

Question 19

linaclotide (linzess) contraindications

Answer 19

<6y, mechanical GI obstruction

Question 20

drug indicated for hospitalized surgery patients to decrease risk of post op ileus

Answer 20

alvimopan

Question 21

laxatives for wbi should be used with caution in which patients

Answer 21

CVD, reanl insufficiency, taking loops or NSAIDs

Question 22

alvimopan (entereg) contraindication and max doses

Answer 22

opioid use > 7 consecutive days; 15 doses

Question 23

constipation drugs only used for OIC

Answer 23

methylnaltrexone, naloxegol, naldemedine

Question 24

drugs that cause diarrhea

Answer 24

AChE Inhibitors, Mg, antibiotics, antidiabetics, antineoplastics, colchicine, laxatives, misoprostol, mycophenolate, metoclopramide, protease inhibitors, quinidine, roflumilast

Question 25

most common bacterial cause for diarrhea

Answer 25

e coli

Question 26

non-drug diarrhea treatment

Answer 26

fluid and electrolyte replacement

Question 27

antidiarrheal agents

Answer 27

bismuth subsalicylate, loperamide, lomotil

Question 28

loperamide boxed warning

Answer 28

torsades, cardiac arrest, do not exceed recommended dose

Question 29

major pepto bismol side effects

Answer 29

black tongue/stool, nausea, bleeding/bruising

Question 30

lomotil cds class

Answer 30

C-V

Question 31

dicyclomine warnings

Answer 31

anticholinergic, mild-mod UC

Question 32

eluxadoline (vibrezi) contraindication

Answer 32

patients without a gallbladder

Question 33

do not take loperamide for longer than

Answer 33

2 days

Question 34

Eluxadoline (Vibrezi) MOA

Answer 34

peripherally acting mixed Mu opioid agonist

Question 35

Methylnaltrexone

Answer 35

Relistor

Question 36

Naloxegol

Answer 36

Movantik

Question 37

Prucalopride MOA and warning

Answer 37

5HT4 agonist; suicidal ideation

Question 38

Imodium bbw and CI

Answer 38

Bbw: cardiac arrest with higher doses CI: c diff, dysentery, enterocolitis

Question 39

Lomotil (diphenoxylate/atropine) CI, side effects and max dose

Answer 39

CI: <2y, <6y if tablets SE: mild euphoria Max 20 mg/day

Question 40

drug used to treat constipation that is only available Rx

Answer 40

lactulose

Question 41

osmoprep boxed warning

Answer 41

nephropathy

Question 42

first line OIC tx

Answer 42

stimulant laxative

Question 43

PAMORAs

Answer 43

alvimopan, mathylnaltrexone, naloxegol, naldemedine

Question 44

amitiza common se

Answer 44

nausea

Question 45

linaclotide (linzess) MOA

Answer 45

guanylate cyclase C agonist