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GERD PUD Flashcards

(53 cards)

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1
Q

which cells secrete HCl in the stomach

A

parietal

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2
Q

diagnosis of GERD involves experience of symptoms how often

A

2 times per week

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3
Q

what drugs can worsen GERD symptoms

A

ASA, NSAIDs, bisphosphonates, dabigatran, estrogen products, fish oil products, iron supplements, NRT, steroids, tetracyclines

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4
Q

when should you refer GERD patient to a doctor

A

2 weeks OTC/lifestyle mods, alarm symptoms (odynophagia, dysphagia, N/V, hematemesis, bloody stoold, unintentional weight loss)

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5
Q

frequent or severe GERD should be treated with

A

8 weeks of PPI

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6
Q

infrequent heartburn should be treated with

A

antacids or H2RAs

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7
Q

couseling point for alka seltzer

A

aspirin component will inc risk of bleeding if used too frequently

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8
Q

calcium SE

A

constipation

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9
Q

aluminum SE

A

constipation

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10
Q

magnesium SE

A

loose stools

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11
Q

alka seltzer contains >500 mg Na which can

A

worsen edema in pt with heart failure or cirrhosis

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12
Q

H2RAs may cause confusion in

A

elderly, severely ill, renal impairment

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13
Q

high dose of cimetidine may cause

A

gynecomastia, impotence

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14
Q

PPIs reversibly/irreversibly bind to the proton pump

A

irreversibly

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15
Q

H2RAs reversibly/irreversibly bind to the H2 receptors

A

reversibly

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16
Q

oral PPIs that must be given before breakfst

A

nexium, prevacid, prilosec

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17
Q

oral PPIs that can be given without regard to meals

A

dexilant, protonix

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18
Q

PPI warnings

A

C diff diarrhea, hypOmagnesemia, vitamin B12 deficiency, osteoporosis bone fracture

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19
Q

PPIs that should NOT be used with clopidogrel

A

omeprazole, esomeprazole

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20
Q

which PPIs are available IV

A

pantoprazole, esomeprazole

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21
Q

which H2RA can be injected

A

famotidine

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22
Q

metoclopramide should not be used in patients with which disease

23
Q

which drugs should be avoided completely if taking H2RAs or PPIs

Study These Flashcards
A

dastinib, pazopanib, risedronate DR and (erlotinib and rilpivirine for PPI only)

24
Q

drugs that require an acidic gut

Study These Flashcards
A

iron, mesalamine, TKIs, cephalosporins, azole antifungals, rilpivirine, atazanavir

25
drugs that bind antacids
bictegravir, dolutegravir, elvitegravir, raltegravir, bisphosphonates, isoniazid, levothyroxine, mycophenolate, quinolones, sotalol, steroids, tetracyclines
26
H2RAs and CNS depressants may cause
delerium, dementia, and cognitive impairment
27
which H2RA should not be used with highest risk QT prolonging drugs
famotidine
28
which H2RA has many drug interactions
cimetidine
29
PPIs inhibit which enzyme
CYP2C19
30
which PPIs should not be used with clopidogrel
omeprazole and esomeprazole
31
h pylori is gram
negative
32
PUD occurs when there is
mucosal erosion in GIT
33
eating will decrease the pain in which type of ulcer
duodenal
34
eating will increase the pain in which type of ulcer
gastric
35
diagnostic test for h pylori
urea breath test (CO2)
36
ACG recommends triple therapy for first line treatment of H pylori if
clarithromycin resistance rates are low; otherwise quadruple therapy
37
h pylori treatments last for
10-14 days
38
quadruple therapy can consist of which drug combinations
bismuth+metronidazole+tetracycline+PPI OR amoxicillin+clarithromycin+metrnidazole+PPI
39
how often is PPI given in h pylori treatment
BID
40
how often are the drugs given in the bismuth treatment for h pylori
QID
41
how often are the drugs given in the amoxicillin treatment for h pylori
BID
42
risk factors for nsaid induced ulcers
>60y, history of PUD, high dose NSAIDs, use more than 1 NSAID, also using anticoag/steroid/SSRI/SNRI
43
NSAIDs should be used in caution in
renal and CV disease
44
celecoxib has ________ GI risk and __________ CV risk
dec, inc
45
Vimovo
naproxen/esomeprazole
46
yosprala
aspirin/omeprazole
47
how is sucralfate cytoprotective
forms physical barrier over ulcer
48
how is misoprostol cytoprotective
prostaglandin analog
49
Dosing considerations for pepcid
Dec dose if crcl <60
50
Which PPIs are taken 60 min before meal, 30 min before meal, and without regard to meals?
60 min: nexium, prevacid, prilosec 30 min: protonix Without regard: dexilant
51
H2RAs and PPIs may cause deficiency of
Vit B12
52
Metoclopramide moa
Dopamine ANTagonist
53
Avoid use in PD
Metoclopramide

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