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MSK Exam 2 > Contractile Proteins > Flashcards

Contractile Proteins Flashcards

1
Q

What is contractile ring made of ?

A

actin and myosin 2

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2
Q

What is the basic organization of actin parallel arrays?

A

actin fibers crosslinked together

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3
Q

Function of myosin V?

A

organelle and vesicle transport

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4
Q

What is filamin and its function?

A

acting binding protein, creates 3D meshwork by binding actin

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5
Q

What is the organization name for actin networks in 3D meshwork ?

A

orthogonal arrays

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6
Q

Funciton of Myosin VI?

A

move vesicles to negative end of actin

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7
Q

What -podia associated with phagocytosis?

A

pseudopodia

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8
Q

Erythrocytes contain spectrin.

What do they do?

A

forms actin network that makes up cortical cytoskeleton

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9
Q

Where would you see an actin contractile bundle?

A

in muscles for contraction

in contractile ring for mitosis

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10
Q

What is the only myosin that moves to negative end of actin?

A

Myosin VI

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11
Q

Which myosin associated with skeletal muscle?

A

Myosin 2

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12
Q

What fiber is important for all the -podias?

A

Actin

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13
Q

What determines the association of actin filaments?

A

size and shape of actin binding proteins

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14
Q

What is DMD?

A

mutation in dystrophin gene resulting in muscle wasting (X linked)

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15
Q

What will myosin with LONGer neck have over myosin with shorter neck?

A

higher velocity powerstroke ( this is referring to length of LIGHT CHAIN NECK PORTION not the tail of the myosin)

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16
Q

Where do you see ATPase activity in Myosin?

A

head

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17
Q

What might be deficient in Hereditary Spherocytosis?

A

ankyrin, spectin, protein 4.1

18
Q

What facilitates cross linking of actin bundles

A

actin bundling proteins

19
Q

Where would you find myosin light chain peptides?

A

neck region of myosin

20
Q

What contributes to prevention of myosin binding to actin in smooth muscle? What enzyme causes this inhibitory state?

A

folding of myosin by regulatory light chain in the neck

myosin light chain kinase

21
Q

Function of MYosin 1?

A

assists with endocytosis

22
Q

What causes a myosin power stroke?

A

release of Pi

23
Q

What does dystrophen gene do?

A

connects cytoskeleton to basal lamina, stabilizes membrane

24
Q

What enzyme in smooth muscle activates myosin ?

A

myosin light chain kinase

25
Q

What end of actin does myosin move towards?

A

myosin light chain kinase

26
Q

What actin bundling protein would you find cross linking actin in microvilli?

A

fimbrin

27
Q

Which myosin would be associated with a membrane?

A

Myosin 1

28
Q

What is required for myosin to release actin?

A

binding ATP

29
Q

What makes up a thin filament?

A

actin, tropomyosin and troponin

30
Q

Function of titin?

A

increases contractility of myosin

31
Q

Function of Nebulin ?

A

keeps discrete length of actin filament

32
Q

Tropomodulin binds where?

A

binds negative end of actin

33
Q

Where is Cap Z located on sarcomere?

A

bound to Z line on (+) end of actin

34
Q

What activates Myosin light chain kinase in smooth muscle contraction?

A

Ca2+ and calmodulin complex

35
Q

DMD are typically expressed as what kind of genetic mutations?

A

OUT of frame

36
Q

BMD is typically what kind of genetic mutation?

A

IN frame mutation ( still has some amount of protein being made with some fxn)

37
Q

What gives skeletal muscle its Ca2+ dependance?

A

troponin

38
Q

What allows myosin to de-attach from actin?

A

Switching of ADP to ATP

39
Q

Rate of actin association is dependent on ?

A

concentration of monomers

40
Q

What are the 3 stages of actin polymer association?

A

nucleation, elongation, steady state

41
Q

what does actin have to be bound to in order for it to polymerize faster?

A

ATP

42
Q

if nebulin doesn’t work, what happens to actin filaments?

A

gets longer (nebulin stops additional monomers from being added)

MSK Exam 2 (7 decks)

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