copd Flashcards

1
Q

features COPD

A

cough // SOB // wheeze // smoking // severe = right HF

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2
Q

bronchitis and emphysema COPD

A

bronchitis = -Smooth muscle spasm and hypertrophy // emphysema = alveolar destruction –> decreased air exchange

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3
Q

CXR COPD

A

hyperinflated // bullae (mimic pneumothorax)

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4
Q

why is FBC required for COPD

A

secondary polycythaemia

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5
Q

diagnosis COPD

A

spirometry - FEV1/FVC <0.7 // FEV1 reduced, FVC normal

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6
Q

stage 1 COPD spirometry

A

FEV1 >80% + symptomatic

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7
Q

stage 2 COPD spirometry

A

FEV 50-79%

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8
Q

stage 3 COPD spirometry

A

FEV1 40-49 % (severe)

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9
Q

stage 4 COPD spirometry

A

FEV1 <30% (V severe)

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10
Q

general mx COPD

A

smoking cessation // influenza vaccine // one off pneumococcal vaccine // pulm rehab

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11
Q

COPD 1st line mx

A

1 = SABA OR SAMA

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12
Q

COPD progressive mx no features asthma

A

1 = SABA or SAMA // 2 = SABA + LABA + LAMA // 3 = theophylline

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13
Q

what featured indicate asthma COPD overlap

A

history atopy // high eosinophils // variation in FEV1 (esp diurnal)

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14
Q

COPD progressive mx with features asthma

A

1 = SAMA OR SAMA // 2 = add LABA + ICS // 3 = SABA + LAMA + LABA + ICS (no LAMA) // 4 = add theophylline

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15
Q

important note with LAMA + SAMA

A

cannot be taken together, if adding LAMA discontinue SAMA

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16
Q

interaction theophylline with abx

A

reduce macrolide (eyrthromycin, clarithromycin) + fluroquinilones (ciprofloxacin)

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17
Q

abx prophylaxis in COPD

A

azithromycin

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18
Q

monitoring with azithromycin

A

ECG (azithromycin prolongs QT interval)

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19
Q

features cor pulmonale COPD

A

peripheral oedema, raised JVP, parasternal heave

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20
Q

mx cor pulmonale COPD

A

diuretics + long term O2

21
Q

methods to improve surviva COPD

A

stop smoking // long term O2 // long volume surgery

22
Q

who should be assessed for long term O2 COPD

A

FEV1 <30% // cyanosis // polycythaemia // peripheral oedema // raised JVP // O2 <92%

23
Q

how is long term O2 COPD assessment done + what results indicate need for it

A

2 ABG 3 weeks apart // pO2 <7.3 // OR pO2 between 7.3-7.8 + one of: polycythaemia, peripheral oedema, pulm HTN

24
Q

who is not suitable for long term O2 COPD

25
indications non-invasive ventilation COPD
resp acidosis pH 7.24-7.35
26
other indications NIV (not COPD)
type II resp failure from deformity // cardiogenic pulm oedema // weaning tracheal intubation
27
medications to help in smoking cessation
nicotine patch // varenicline // bupropion (monotherapy only)
28
when can repeat prescirption for smoking cessation be offered
after 6 months
29
use nicotine therapy smoking cessation
patches (+ gum, inhaler etc if needed)
30
mechanism Varenicline
nicotinic receptor agonist
31
SE Varenicline
nausea, headache, insomnia // caution with depression
32
mechanism Bupropion
NA + dopamine reuptake inhibitor // nicotine antagonist
33
SE + contraindication Bupropion
SE = seizures // contraindicated in epilsey, pregnancy, breast feeding, eating disorder
34
smoking cessation in pregnancy + breast feeding
CBT --> NRT // others contraindicated
35
what is Alpha-1 antitrypsin deficiency
inherited disorder causing COPD in young non-smokers
36
inheritance + genetics Alpha-1 antitrypsin deficiency
chromosome 14 // autosomal recessive or co-dominant
37
alleles Alpha-1 antitrypsin deficiency
M = normal, S = slow, Z = v slow
38
homozygous PiSS levels
50% normal Alpha-1 antitrypsin levels
39
homozygous piZZ levels
10% normal Alpha-1 antitrypsin
40
features Alpha-1 antitrypsin deficiency
normally PiZZ // emphysema in LOWER lobes // liver cirrhosis, hepatocellular carcinoma
41
invx Alpha-1 antitrypsin deficiency
A1AT // spirometry - obstructive picture
42
medical + lifetyle mx Alpha-1 antitrypsin deficiency
no smoking // supportive + physio // IV Alpha-1 antitrypsin //
43
surgical mx Alpha-1 antitrypsin deficiency
lung volume reduction surgery OR transplant
44
cause AECOPD
H influe!! // strep pneumo, moraxella // virus
45
mx community/ at home AECOPD
increase LABA + LAMA // 30mg pred 5 days
46
when are abx indicated COPD + what is given
purulent sputum or pneumonia --> amox / doxy / clarithro
47
admission AECOPD
severe SOB // confusion or reduced LOC // cyanosis // O2 sats <90% // cant look after themselves at home // comorbid
48
mx severe/ hospitalised AECOPD
neb LABA + LAMA // IV hydrocortisone // IV theophylline // NIV