copy 2

Question 1

What is the origin of the adrenal cortex?

Answer 1

mesoderm

Question 2

Describe the gradual development of the adrenal cortex?

Answer 2

Week 4 – 6 : start from coelomic
mesoderm adjacent to
urogenital ridge

Week 8: differentiate into thin definite
outer cortex and thick inner fetal cortex

Fetal cortex produce steroid during gestation
and involutes at birth.

Definite cortex develop into functional adrenal
cortex

Question 3

What is the medulla derived from and with what system does it develop with?

Answer 3

Medulla derived from neural crest cells

Develop with sympathetic nervous system

Question 4

Describe the development of the adrenal medulla?

Answer 4

Week 5: neural crest cell migrate to
Para-aortic and Para-vertebral
region towards medial aspect of
adrenal cortex

Question 5

What is the histological composition of the three layers of the adrenal cortex?

Answer 5

Zona glomerulosa: small cells with
intermediate no. of lipid inclusions

Zona fasiculata: Large foamy cells with lipid inclusions -75% of cortex

Zona Reticularis : consists of compact
cytoplasm and few lipid inclusions

Question 6

Are the three zones of the adrenal cortex present at birth?

Answer 6

Zona glomerulosa and fasiculata present at birth

Zona reticularis develops during first year of life

Question 7

Label

Answer 7

Question 8

Label

Answer 8