Copy of Drug List - Test 3 Compiled (1) Flashcards Preview

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1

Drug Name

Drug Class
Mechanism
Special side effects
Use

2

esomeprazole

-Proton Pump Inhibitors
-Irreversible H/K ATPase inhibit
-rebound hypergastrinemia, CYP enz->increase in warfarin levels & decreased clopidogrel levels,
-All stomach acid things (GERD, gastric/duodenal ulcer, Zollinger-Ellison, erosive esophagitis, H. Pylori treatment, NSAID ulcers)

3

lansoprazole

-Proton Pump Inhibitors
-Irreversible H/K ATPase inhibit
-rebound hypergastrinemia, CYP enz->increase in warfarin levels & decreased clopidogrel levels,
-All stomach acid things (GERD, gastric/duodenal ulcer, Zollinger-Ellison, erosive esophagitis, H. Pylori treatment, NSAID ulcers)

4

omeprazole

-Proton Pump Inhibitors
-Irreversible H/K ATPase inhibit
-rebound hypergastrinemia, CYP enz->increase in warfarin levels & decreased clopidogrel levels,
-All stomach acid things (GERD, gastric/duodenal ulcer, Zollinger-Ellison, erosive esophagitis, H. Pylori treatment, NSAID ulcers)

5

cimetidine

-H2 receptor antagonists
-H2 block (from ECL cell)
-long-term: down testosterone & estradiol (gynecomastia, impotence, galactorrhea), rarely CNS effects parenterally, tolerance in 3 days, rebound
-Zollinger-Ellison, decrease nocturnal acid secretion (requires 4 wks)

6

famotidine

-H2 receptor antagonists
-H2 block (from ECL cell)
-rarely CNS effects parenterally, tolerance in 3 days, rebound
-Zollinger-Ellison, decrease nocturnal acid secretion (requires 4 wks)

7

ranitidine

-H2 receptor antagonists
-H2 block (from ECL cell)
-rarely CNS effects parenterally, tolerance in 3 days, rebound
-Zollinger-Ellison, decrease nocturnal acid secretion (requires 4 wks)

8

sucralfate

-Misc. (coating)
-sticky neutral pH coating
-block absorption of other drugs (but requires acid activation)
-stress ulcers (sticks to duodenum better)

9

aluminum hydroxide

-neutralizing antacids
-
-delays gastric emptying, slows motility, rebound
-slow-acting acid neut.

10

calcium carbonate

-neutralizing antacids
-
-rebound
-acid neut.

11

magnesium hydroxide

-neutralizing antacids
-
-stim gastric emptying, rebound
-fast-acting acid neut.

12

magnesium trisilicate

-neutralizing antacids
-
-stim gastric emptying, renal stones, rebound
-fast-acting acid neut.

13

misoprostol

-prostaglandin analog
-PGE1 analog
-exacerbate inflam. bowel disease, abortion (uterine contract)
-Prevent NSAID gastric injury (PPI's better)

14

pirenzepine

-M1 antagonists
-stops signal from vagal nerve (down acid secretion)
-anticholinergic effects
-rarely used

15

bethanechol

-cholinergic ag (prokinetic agent)
-general constriction of whole intestine
-anti-ACh effects
-help urinate, prokinetic motility

16

erythromycin

-antibiotic (prokinetic agent)
-motilin agonist
-fast painful dumps
-counter an ileus

17

metoclopramide

-DA antagonist (prokinetic agent)
-block DA->increased coordinated ACh release
-Parkinson's-like, dyskinesia
-antiemetic, up esophageal sphincter tone (GERD), up GI motility

18

neostigmine

-AChE inhibitor (prokinetic agent)
-general constriction of whole intestine
-ACh effects
-counter an ileus

19

tegaserod

-5-HT4 agonist
-stim intestinal sensory neurons
-fatal arrythmias
-females w/ irritable bowel syndrome

20

cisapride

-5-HT4 agonist (prokinetic agent)
-stim intestinal sensory neurons via 5-HT4 & adenylate cyclase
-fatal arrythmias
-GERD

21

heparin sulfate

-anticoagulant- indirect thrombin inhibitor
-binds antithrombin up flexibility catalyzes activity (blocks IIA,IXa,Xa)
-Bleeding, allergy, thrombosis, osteoporosis. NEVER GIVE INTRAMUSC!
-Acute Tx of DVT and PE. Sometime venous thrombosis and DIC

22

protamine sulfate

-heparin antagonist
-cationic peptide binds heparin and inhibits anticoagulant activity
-allergies (fish)?
-reverse heavy heparin after surgery

23

rivaroxaban

-anticoagulants
-Factor Xa inhibitor, liver/renal/faecal-biliary clearance
-
-

24

warfarin

-anticoagulant
- inh. Vit K metab--> disrupts gamma-carboxylation of II, VII, IX, X, C, S.
-bleeding, skin necrosis, teratogen, thrombosis
-prevent blood clots- 3 day warfarinization needs heparin start

25

menadione

-warfarin antidote- vit K
-
-
-

26

dalteparin

- low molecular weight heparins- indirect thrombin inhibitor
-enhances antithrombin action on factor X
-
-Tx=MI, angina, thrombophlebitis Prevent=clots etc.

27

enoxaparin

-low molecular weight heparins- indirect thrombin inhibiotor
-enhances antithrombin action on factor X
-
-Tx=MI, angina, thrombophlebitis Prevent=clots etc.

28

fondaparinux

-Xa inhibitor- indirect thrombin inhibitor
- pentasaccharide inhibits Xa, renal clearance
-bleeding hemmorhage
-SubQ for DVT, PE prevention following surg,

29

argatroban

-direct thrombin inhibitors
-inhibits thrombin, hepatic clearance
-
-parenteral in heparin contraindicated individuals

30

bivalirudin

-direct thrombin inhibitors
-inhibits thrombin, hepatic and renal clearance
-
-parenteral in heparin contraindicated individuals