GI drugs II Flashcards Preview

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Flashcards in GI drugs II Deck (39)
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1

Methylcellulose

-bulk forming laxative
-Non digestible fiber bulk induces peristalsis
- absorbs other drugs, worsens bowel obstructions.

2

Polycarbophil

-bulk forming laxative
-Non digestible fiber bulk induces peristalsis
- absorbs other drugs, worsens bowel obstructions.

3

psylium

-bulk forming laxative
-Non digestible fiber bulk induces peristalsis
- absorbs other drugs, worsens bowel obstructions.

4

Bismuth subsalicyclate

-antidiarrheal agent (pepto bismol)
-mechanism not understood
-Naturally pink/safe.

5

diphenoxylate

-antidiarrheal agent
-opioid with CNS effects
-packaged with atropine to discourage abuse.

6

loperamine

-antidiarrheal agent
-opioid WITHOUT CNS effects
-50x more powerful than morphine

7

octreotide (AKA Somatostatin)

-antidiarrheal agent
-inhibits gastrin and serotonin decreasing motility
-used for: tumors

8

chlorpromazine

-anti nausea/antiemetic agent
-D2 and H1 antagonist in CTZ
-effective: motion sickness, chemotherapy.
-may cause parkinson like symptoms
(not as effective as metoclopramide for chemotherapy induced nausea)

9

cyclizine

-antiemetic agent
-H1 receptor antagonist
-useful with abdominal cancer patients

10

dimenhydrinate

-antiemetic agent (Dramamine)
-H1 receptor blocker

11

dolasetron

-antiemetic agent
-5HT receptor antagonist which prevents CTZ and STN stimulation.
-8 hours

12

hydroxyzine

-antiemetic agent
-H1 receptor antagonist

13

granisetron

-antiemetic agent
-5HT receptor antagonist which prevents CTZ and STN stimulation.
-10 hours

14

metoclopramide

-antiemetic agent
-dopamine receptor antagonist
-Chemo induced nausea, antiphychotic agent.

15

ondansetron

-antiemetic agent
-5HT receptor antagonist which prevents CTZ and STN stimulation.
-4 hours

16

palonosetron

-antiemetic agent
-5HT receptor antagonist which prevents CTZ and STN stimulation.
-40 hours and parenteral only.
(unique b/c excreted both by liver and kidney unlike the other emetics which are only liver)

17

prochlorperazine

-anti nausea/antiemetic agent
-D2 and H1 antagonist in CTZ
-effective: motion sickness, chemotherapy.
-may cause parkinson like symptoms

18

promethazine

-anti nausea/antiemetic agent
--H1 receptor antagonist
-widely used for post op emesis and motion sickness.

19

scopalamine

-antiemetic agent
-Muscarinic Ach antagonist that acts primarily on the vestibular apparatus (inner ear)
-Very effective for short term motion sickness
-may cause uncontrolled behavior.

20

apomorphine

-emetic agent (dopamine agonist)
-acts locally and on CTZ
-only given sub Q, replaced by charcoal.

21

ipecac

-emetic agent
-acts on CTZ
-replaced by charcoal.

22

6-mercaptopurine

-bowel disease
-Prevents DNA synthesis (converted to 6-thioguanine)
-used with UC and Crohn's for remission, also for fistulas, can cause pancreatitis and bone marrow suppression.

23

adalimumab

-bowel disease
-Anti TNF antibodies
-Mantain UC and Crohn remission, increased risk for upper respiratory tract infections.

24

alosetron

-bowel disease
-5HT3 antagonist
-used to treat diarrhea. (recall serotonin speeds up intestinal transit time)

25

azathioprine

-bowel disease
-Prevents DNA synthesis (converted to 6-thioguanine)
-used with UC and Crohn's for remission, also for fistulas, can cause pancreatitis and bone marrow suppression.

26

budesonide

-Glucocorticoid (topical inside bowel)
-inhibit immune and inflammatory response.
-not absorbed from GI

27

infliximab

-bowel disease
-Anti TNF antibodies (Humanized mouse antibody)
-Mantain UC and Crohn remission, increased risk for upper respiratory tract infections.

28

mesalamine

-IBD treatment (UC and Crohn's)
-(AKA 5 amino salicylic acid)
-active component that acts by decreasing TNF alpha activity.
-activated in small intestine, may cause nephritis

29

olsalazine

-IBD treatment (UC and Crohn's)
-Inactive precursor converted to MESALAMINE which act by decreasing TNF alpha activity.
-active in colon only

30

prednisone

-Glucocorticoid
-decrease immune and inflammation response
-cushing syndrome.