CPT HTN

Question 1

common ADR furosemide

Answer 1

INCREASED LDL CHOLESTEROL

Question 2

NICE guidelines for pre hypertension

Answer 2

> 130/90

Question 3

NICEguidelines for hypertension

Answer 3

> 140/90

Question 4

CCB with greatest selectivity for vascular smooth muscle

Answer 4

amlodipine

Question 5

CCB with greatest selectivity for cardiac tissue

Answer 5

verapamil

Question 6

what should be given with a statin as secondary prevention

Answer 6

ezetimibe

Question 7

combination of which hyperlipidaemia inc rhabdomyolysis risk?

Answer 7

fenofibrate and statin

> sometimes given together in familial hypercholesterolaemias.

Question 8

what is the role of endothelin?

Answer 8

causes vasoconstriction

> statins reduce endothelin

Question 9

which drugs are given post MI

Answer 9

ACEi/ARB
Dual antiplatelet therapy.
beta-blocker.
statin.

Question 10

what is given for the dual anti platelet therapy post MI

Answer 10

clopidogrel (12 months)

aspirin

Question 11

amiodarone can act on what channels

Answer 11

its a class 3 antiarrythmic

but can act on Na, K and Ca

and act as non competitive beta blocker

Question 12

fleccanide effect on AP duration

Answer 12

increases it
as slows tissue conduction during phase 0

> therefore increases PR interval

reduces the atrial rate sufficiently to allow all APs thru> possibly cause ventricular tachycardia

Question 13

why is beta blocker prescribed with flecanide

Answer 13

to prevent 1:1 conduction through AV node.

> prevent possibility of ventricular tachycardia.

Question 14

why do NSAIDs cause GI ADRs

Answer 14

• decreased mucus secretion
• dec bicarb secretion
• reduced mucosal blood flow
• inhibition of PGE2 and PG12 major factor