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Year2 MSK exam2 > CTD part I > Flashcards

CTD part I Flashcards

1
Q

autoimmune MHC I more common in

A

men

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2
Q

autoimmune MHC II more common in

A

women

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3
Q

AutoAb in SLE

A

+ ANA HLA B8 HLA DR2 and DR3 W>M black>white

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4
Q

what deficiencies are assoc with SLE

A

C1 C2 and C4

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5
Q

28 F arthralgias, chest pain dyspnea, malar rash on face, 2/6 systolic murmur scartchin sound L lower lung pedal edema elevated ESR troponin inc, moderate proteinuria

A

SLE

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6
Q

11 Criteria for SLE!!!!!

A

-hematologic disorder: pancytopenia -immunologic disorder: dsDNA or SmAg, APA or FPSTS -ANA -Oral ulcers -Renal disorder: protein or casts -Neurologic disorder: seizure or psychosis -malar rash -discoid rash -photosensitivty -arthritis -serostitis :pleuritis or pericarditis

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7
Q

ST elevations in every lead

A

pericarditis

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8
Q

ANA subtpes

A

Ro SS-A La SS-B Sm U1-RNP Scl70/topoisomerase 1 Jo-1

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9
Q

peripheral rim pattern cytology

A

SLE

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10
Q

speckled pattern cytology

A

SLE and sjogrens polymyositis and dermatomyositis PSS

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11
Q

anti centromere pattern cytology

A

PSS (CREST) progessive systemic sclerosis

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12
Q

nucleolar pattern cytology

A

SLE and PSS

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13
Q

telescoping urinary sediment

A

casts, WBC or RBC or protein etc.

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14
Q

urinary findings in SLE

A

casts proteinuria >500 mg in 24 hrs 3+ protein on dipstick

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15
Q

SLE CNS involvement

A

seizures psychoses

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16
Q

what makes SLE rashes worse

A

smoking

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17
Q

reversible swan neck deformtiies

A

SLE arthritis

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18
Q

cardiopulm involvement with sLE

A

alveolar hemorrhage (cough up blood) libman sacks endocarditis (not infectious)

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19
Q

Tx for SLE

A

hydroxychloroquine

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20
Q

what does hydroxychloroquine do in SLE Tx

A

reverse platelet activaiton by IgG antiphospholipid prevents flares reduces congenital heart block reduce DM risk

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21
Q

causes of splinter hemorrhages

A

nail truama SBE sntiphospholipid Ab syndrome hyper-eos syndrome

22
Q

risk factors for libman sacks vegetations

A

lupus nephritis anticardiolipin Ab

23
Q

what cause atypical verrucous vegetations with marantic non bacterial thrombotic endocarditis

A

aka: libman sack mitral regurg SLE causes this

24
Q

What drugs can trigger autoimmunogenicity

A

hydralazine isoniazid procainamide methimazole propylthiouracil etanercept slow acetylators

25
inhibit DNA methylation in T helper cells
become autoreactive
26
what is an important screening test for pregnant woman with lupus
lupus anticoagulant because pregnancy is a prothrombotic state also La and antiphospholipid Ab, apolipoprotein H to exclude APS
27
pregnancy is most hazardous in what SLE patients
those with concurrent HTN and renal disease, APS and RO Ab
28
what drugs are safe in pregnancy for SLE
HCQ
29
what drugs are not safe for pregnancy in SLE
mycophenolate, cyclophosphamide, MTX azathrioprine
30
what indicates lupus flare and not preeclampsia
low C3 C4 uric acid levels normal in SLE flare
31
indications of preeclampsia
uric acid high abn LFTs
32
Hx deficiency C'2 most likely Ab
Ro/SS-A
33
photosensitivty with C' deficiency may have daughter with what
heart block
34
SCSLE rash
spares knuckles and face nonindurated non scaring erythematous plaques papulosquamous or annular lesions with cental hypopigmentation or telangiectasia sun exposed areas
35
SCLE rash also seen in
RA and SS
36
What drug can cause SCLE rash
HCTZ
37
screen for what when see the SCLE rash
anti Ro anti La Ab
38
neonatal lupus affect children born to mothers with what Ab
Anti-Ro SS-A or La SS-B
39
what is transient in neonatal lupus
rashes- SCSLE thrombocytopenia hemolytic anemia arthritis
40
what is permanent in neonatal lupus
complete heart block
41
Tx of neonatal lupus
HCQ
42
50 y.o with PMH + 2 spontaneous abortions and TIA fater + stroke DVT in L arm, abdominal ecchymosis from LMWH injections hemosiderin deposits visible in LE prolonged INR and PTT low platelet count Check what Ab?
lupus anticoagulnt
43
What is APS
antiphospholipid Ab syndrome
44
causes of secondary APS
CTDs malignancy infections (HIV) drugs: phenytoin, chlorpromazine
45
Dx of APS
1 clinical + 1 lab 3 mo apart
46
clinical criteria APS
spontaneous abortion vascular thrombosis
47
lab criteria APS
anticardiolipin Ab lupus anticoagulant Anti B2 glycoprotein 1 (ApoH) false + serologic test for syphilis
48
type of rash
discoid lupus erythema
49
what are these
splinter hemorrhages assoc with SLE
50
identify rash
subacute cutaneous lupus erythematosus RA SS and SLE watch out for heartblock in daughter

Year2 MSK exam2 (17 decks)

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